Catalogue number
HIV-142
Introduction
Human T-lymphotropic virus (HTLV) is a human, single-stranded RNA retrovirus that causes T-cell leukemia and T-cell lymphoma. The virus activates a subset of T-helper cellscalled Th1cells. The result is a proliferation of Th1 cells and overproduction of Th1 related cytokines (mainly IFN-gamma and TNF-alpha). Feedback mechanisms of these cytokines cause a suppression of the Th2 lymphocytes and a reduction of Th2 cytokine production (mainly IL-4, IL-5, IL-10 and IL-13). The end result is a reduction in the ability of the infected host to mount an adequate immune response to invading organisms that require a predominantly Th2 dependant response (these include parasitic infections and production of mucosal and humoral antibodies).
Description
The E.Coli derived recombinant mosaic protein contains the gp46 immunodominant regions, 162-214 amino acids and 242-257 amino acids, Mw on SDA-PAGE is 39kDa.
Purification Method
HTLV-1 gp46 was purified by proprietary chromatographic technique.
Purity
HTLV-1 gp46 protein is >95% pure as determined by 10% SDS-PAGE (coomassie staining) and RP-HPLC.
Formulation
10mM NaPO4 pH 6.0, 0.1% SDS, 1mM DTT, 1mM EDTA.
Stability
HTLV-1 gp46 although stable at 4°C for 1 week, should be stored below -18°C.
Please prevent freeze thaw cycles.
Safety Data Sheet
Usage
ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
