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品牌：List Labs 

货号：611A

品名：List Labs Botulinum Neurotoxin Type A Light Chain, Recombinant, GST Fusion

中文名：

规格：15 ug

纯度：>85%

形式：lyophilized powder

储存温度：2-8°C

描述：

Clostridium botulinum neurotoxins (BoNTs) block the release of acetylcholine from peripheral cholinergic nerve endings  causing botulism in man and animals.  Seven immunologically distinct serotypes of neurotoxin, designated types A through G, have been identified.  Each is synthesized as a single polypeptide chain (MW 150,000), the holotoxin.  These holotoxins become embedded in a complex formed from hemagglutinins and non-hemagglutinating proteins, which enhance oral toxicity by stabilizing the neurotoxins.1 When botulinum neurotoxin is exposed to proteases, either during cultivation or subsequent to purification of the toxin, specific peptide bonds are cleaved or “nicked” resulting in the formation of a dichain molecule.  Dichain neurotoxin is composed of a light chain region (MW 50,000) linked by a single disulfide bond and non-covalent interactions to a heavy chain (MW 100,000).Conversion of the single chain form of a neurotoxin to its dichain form generally results in increased toxicity.7 When the light and heavy chains of botulinum toxin are separated from one another, neither is capable of blocking neurotransmitter release in unaltered cells. However, the light chain alone is capable of blocking acetylcholine release if injected directly into the cell cytosol.

注：产品仅用于研究目的，不得用于人体或作为诊断剂。