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PCT (Detection) Antibody (Biotin) against Human. Procalcitonin (PCT) is a peptide precursor of the hormone calcitonin, the latter being involved with calcium homeostasis. It is composed of 116 amino acids and is produced by parafollicular cells (C cells) of the thyroid and by the neuroendocrine cells of the lung and the intestine. Measurement of procalcitonin can be used as a marker of severe sepsis caused by bacteria and generally grades well with the degree of sepsis, although levels of procalcitonin in the blood are very low. PCT has the greatest sensitivity (85%) and specificity (91%) for differentiating patients with systemic inflammatory response syndrome (SIRS) from those with sepsis, when compared with IL-2, IL-6, IL-8, CRP and TNF-alpha. It is a biomarker of bacterial infection which may help gauge the severity and prognosis of patients with CAP. In addition to clinical predictors, PCT may assist in decisions pertaining to timing of discharge from hospital and the discontinuation of antibiotics.

It is recommended to use abx019247 as the capture antibody and abx019248 or abx019264 (this product) as the detection antibody.

Target	PCT
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Tested Applications	ELISA, WB, CLIA, TIA
Recommended dilutions	Optimal dilutions/concentrations should be determined by the end user.
Immunogen	Recombinant PCT protein.
Purity	> 95% by HPLC & SDS-PAGE.
Purification	Protein A or G purified.
Form	Liquid
Isotype	IgG1
Conjugation	Biotin
Specificity	Specifically recognises human PCT.
Storage	Aliquot and store at -20°C for long-term storage. Avoid repeated freeze and thaw cycles.
Buffer	0.01 M PBS (pH7.4) and 0.15 M NaCl. Does not contain preservatives.
Availability	Shipped within 5-10 working days.
Note	This product is for research use only.