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SR9243, LXR inverse agonist

品牌：AG Scientific

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规格：25 mg

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CAS:1613028-81-1Formula:C31H32BrNO4S2MW:626.62Appearance:WhitesolidPurity:>98%byHPLCNMR(Conforms)

商品详情参考文献相关资料

SR9243 (1613028-81-1) is an LXR inverse agonist that significantly inhibits the Warburg effect and lipogenesis by reducing glycolytic and lipogenic gene expression. Induces apoptosis in a variety of cancer cell types including SW620 (IC₅₀ = 40 nM), HT-29 (IC₅₀ = 104 nM), DU-145 (IC₅₀ = 15 nM), PC-3 (IC₅₀ = 61 nM), NCI-H23 (IC₅₀ = 72 nM), HOP-62 (IC₅₀ = 26 nM) and MIAPACA-2 (IC₅₀= 18 nM). SR9243 is able to promote apoptotic cancer cell death without adversely affecting non-malignant cells.

Additional Information

Product #	S-3335
CAS #	1613028-81-1
Chemical Name	N-[2-(3-Bromophenyl)ethyl]-2,4,6-trimethyl-N-[[3Õ-(methylsulfonyl)[1,1Õ-biphenyl]-4-yl]methyl]-benzenesulfonamide
Formula	C₃₁H₃₂Br_NO₄S₂
MW	626.62
Appearance	White solid
Purity	>98% by HPLC NMR (Conforms)
Solubility	Soluble in DMSO (greater than 25 mg/ml)
Storage Temp	-20°C (des.)