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Enzastaurin

品牌：AG Scientific

货号：

规格：1 mg

货期：

应用：

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CAS:170364-57-5Formula:C32H29N5O2MW:515.61Appearance:SolidPurity:99%

商品详情参考文献相关资料

Enzastaurin (Enz) is a potent and selective inhibitor of PKC with antiproliferative activity (IC= ~6 nM). Binding to the ATP-, enzastaurin selectively inhibits Protein kinase & protein kinase C beta. Enz suprpresses VEGF-induced angiogenesis in the rat corneal micropocket assay, decreases microvessel density, and prevents VEGF secretion from human tumor cell xenografts in nude mice. Prolonged courses of Enz increase chemotherapy or radiation tumor growth delay of glioma, breast, and small cell lung cancer xenografts.

Additional Information

Synonyms	LY317615
Product #	E-2048
CAS #	170364-57-5
Chemical Name	3-(1-METHYLINDOL-3-YL)-4-[1-[1-(PYRIDIN-2-YLMETHYL)PIPERIDIN-4-YL]INDOL-3-YL]PYRROLE-2,5-DIONE
Formula	C₃₂H₂₉N₅O₂
MW	515.61
Appearance	Solid
Purity	99%
Solubility	DMSO
Storage Temp	Keep cool and dry. Store at -20°C
Therapeutic Area	Oncological Disorders
Use	Enzastaurin is a synthetic bisindolylmaleimide with potential antineoplastic activity

Additional Information

MDL Number	MFCD11040980
ChemACX	X1722797-7
InChI	InChI=1S/C32H29N5O2/c1-35-19-25(23-9-2-4-11-27(23)35)29-30(32(39)34-31(29)38)26-20-37(28-12-5-3-10-24(26)28)22-13-16-36(17-14-22)18-21-8-6-7-15-33-21/h2-12,15,19-20,22H,13-14,16-18H2,1H3,(H,34,38,39)
SMILES	Cn1cc(c2c1cccc2)C3=C(C(=O)NC3=O)c4cn(c5c4cccc5)C6CCN(CC6)Cc7ccccn7

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