Dorsomorphin Inhibit Myostatin / GDF8 Signaling, inhibits Bmp-Smad pathway |产品详情|进口榴莲视频免费观看采购网

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Dorsomorphin Inhibit Myostatin / GDF8 Signaling, inhibits Bmp-Smad pathway

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Dorsomorphin Inhibit Myostatin / GDF8 Signaling, inhibits Bmp-Smad pathway

品牌：AG Scientific

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规格：5 mg

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CAS:866405-64-3Formula:C24H25N5OMW:399.5Appearance:YellowSolidPurity:>98%(TLC)

商品详情参考文献相关资料

Cell-permeable. A potent, selective, reversible and ATP-competitive inhibitor of AMP-activated protein kinase (AMPK) (Ki=109 nM in the presence of ATP and no AMP). Displays no significant inhibition of JAK3, PKA, PKCθ, SYK and ZAPK. Suppresses food intake in mice and inhibits the effects of AICAR and metformin.Also inhibits bone morphogenic protein (BMP) type I receptors (ALK2, ALK3 and ALK6). Promotes cardiomyogenesis in mouse embryonic stem cells. In addition, recently Dorsomorphin has shown to induce protective autophagy in cancer cells through AMPK inhibition-independent pathway.

Additional Information

Synonyms	BML-275; Compound C; AMPK INHIBITOR
Product #	D-1310
CAS #	866405-64-3
Chemical Name	6-[4-(2-Piperidin-1-yl)-ethoxy)- phenyl)]-3-pyridin-4-yl- pyrazolo[1,5-a]-pyrimidine
Formula	C₂₄H₂₅N₅O
MW	399.5
Appearance	Yellow Solid
Purity	>98%(TLC)
Solubility	May be dissolved in DMSO (4 mg/ml, warm).
Melting Point	244.93 °C
Storage Temp	Store desiccated at -20°C. Store solutions at -20°C for up to 3 months
Therapeutic Area	Neurological Disorders
Use	A potent inhibitor of AMPK

Additional Information

MDL Number	MFCD08705402
ChemACX	X1561649-0
InChI	InChI=1S/C24H25N5O/c1-2-12-28(13-3-1)14-15-30-22-6-4-19(5-7-22)21-16-26-24-23(17-27-29(24)18-21)20-8-10-25-11-9-20/h4-11,16-18H,1-3,12-15H2
SMILES	C1CCN(CC1)CCOC2=CC=C(C=C2)C3=CN4C(=C(C=N4)C5=CC=NC=C5)N=C3

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