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ML239,BreastCancerStemCellInhibitor

品牌：Xcessbio

货号：M60282-2s

规格：2 mg solid

货期：

应用：

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ML239,BreastCancerStemCellInhibitor

商品详情参考文献相关资料

Product Information

Molecular Weight:	346.60
Formula:	C₁₃H₁₀Cl₃N₃O₂
Purity:	≥98%
CAS#:	1378872-36-6
Solubility:	DMSO up to 100 mM
Chemical Name:	(E)-N'-((1H-pyrrol-2-yl)methylene)-2-(2,4,6-trichlorophenoxy)acetohydrazide
Storage:	Powder: 4^oC 1 year. DMSO: 4^oC 3 month; -20^oC 1 year.

Biological Activity:

ML239 is a potent and selective breast cancer stem cell inhibitor with IC50 ~1.16 μM. It displayed greater than 23-fold selective inhibition of the breast CSC-like cell line (HMLE_sh_Ecad) over the isogenic control cell line (HMLE_sh_GFP). It did not significantly inhibit tumorsphere formation in the breast cancer cell line SUM159, which is a mixture of CSCs and differentiated cells. ML239 is also cytotoxic towards MDA-MB-231 breast cancer cells.

How to Use:

In vitro: ML239 was used at 10 µM final concentration in vitro and in cellular assays.
In vivo: n/a

Reference:

1. Carmody LC, et al. Phenotypic high-throughput screening elucidates target pathway in breast cancer stem cell-like cells. (2012) J Biomol Screen. 17(9):1204-10.
2. Germain AR, et al. Identification of a selective small molecule inhibitor of breast cancer stem cells. (2012) Bioorg Med Chem Lett. 22(10):3571-4.
3. http://www.ncbi.nlm.nih.gov/books/NBK133423/

Products are for research use only. Not for human use.

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