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Anti-FAT4 Antibody

品牌：Antibodies

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规格：100µl

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Anti-FAT4 Antibody

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Overview

Name:	Anti-FAT4 Antibody See all FAT4 primary antibodies
Description:	Rabbit polyclonal antibody to FAT4
Specificity:	The antibody detects endogenous levels of total FAT4 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to residues near the C terminal of human FAT tumor suppressor homolog 4 (Drosophila)
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	0.7mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Cadherins are calcium-dependent cell adhesion proteins. FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
Tissue Specificity:	Widely expressed. Expressed in fetal brain, infant brain, brain tumor and colorectal cancer.
Involvement in Disease:	Van Maldergem syndrome 2: An autosomal recessive disorder characterized by intellectual disability, typical craniofacial features, auditory malformations resulting in hearing loss, and skeletal and limb malformations. Some patients have renal hypoplasia. Brain MRI typically shows periventricular nodular heterotopia. Hennekam lymphangiectasia-lymphedema syndrome 2: A form of Hennekam lymphangiectasia-lymphedema syndrome, a generalized lymph-vessels dysplasia characterized by intestinal lymphangiectasia with severe lymphedema of the limbs, genitalia and face. In addition, affected individuals have unusual facies and severe mental retardation. HKLLS2 individuals have lymphangiectasia variably affecting the gut, pericardium, lungs, kidneys, and genitalia. Other features include camptodactyly and rare syndactyly.
Cellular locations:	Membrane. In the kidney, localizes to primary cilia.
Database Links:	Entrez Gene: 79633?Human SwissProt: Q6V0I7?Human Unigene: 563205?Human
Synonyms:	Cadherin family member 14 Antibody Cadherin related family member 11 Antibody CDHF14 Antibody CDHR11 Antibody FAT atypical cadherin 4 Antibody FAT J Antibody FAT tumor suppressor homolog 4 Antibody Fat-like cadherin protein FAT-J Antibody FAT4 Antibody FAT4_HUMAN Antibody FATJ Antibody hFat4 Antibody HKLLS2 Antibody Nbla00548 Antibody Protocadherin Fat 4 Antibody Putative protein product of Nbla00548 Antibody VMLDS2 Antibody
Information:	Target information shown above is from the UniProt Consortium.