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Anti-FADD Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

应用：

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Anti-FADD Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-FADD Antibody See all FADD primary antibodies
Description:	Rabbit polyclonal antibody to FADD.
Applications:	WB, IHC
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human FADD.
Protein Length:	208
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling.
Tissue Specificity:	Expressed in a wide variety of tissues, except for peripheral blood mononuclear leukocytes.
Involvement in Disease:	Infections, recurrent, associated with encephalopathy, hepatic dysfunction and cardiovascular malformations: A condition with biological features of autoimmune lymphoproliferative syndrome such as high-circulating CD4(-)CD8(-)TCR-alpha-beta(+) T-cell counts, and elevated IL10 and FASL levels. Affected individuals suffer from recurrent, stereotypical episodes of fever, encephalopathy, and mild liver dysfunction sometimes accompanied by generalized seizures. The episodes can be triggered by varicella zoster virus (VZV), measles mumps rubella (MMR) attenuated vaccine, parainfluenza virus, and Epstein-Barr virus (EBV).
Database Links:	Entrez Gene: 8772?Human Entrez Gene: 14082?Mouse Entrez Gene: 266610?Rat Omim: 602457?Human SwissProt: Q13158?Human SwissProt: Q61160?Mouse Unigene: 86131?Human Unigene: 5126?Mouse Unigene: 16183?Rat
Synonyms:	FADD Antibody FADD protein Antibody FADD_HUMAN Antibody Fas (TNFRSF6) associated via death domain Antibody Fas associated via death domain Antibody Fas associating death domain containing protein Antibody Fas associating protein Antibody Fas associating protein with death domain Antibody Fas TNFRSF6 associated via death domain Antibody FAS-associated death domain protein Antibody FAS-associating death domain-containing protein Antibody GIG 3 Antibody GIG3 Antibody Growth inhibiting gene 3 protein Antibody Growth-inhibiting gene 3 protein Antibody H sapiens mRNA for mediator of receptor induced toxicity Antibody Mediator of receptor induced toxicity Antibody MGC8528 Antibody MORT 1 Antibody MORT1 Antibody Protein FADD Antibody
Information:	Target information shown above is from the UniProt Consortium.