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Anti-ErbB-3 (E1218) Antibody

品牌：Antibodies

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规格：50µl

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Anti-ErbB-3 (E1218) Antibody

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Overview

Name:	Anti-ErbB-3 (E1218) Antibody See all ErbB3 primary antibodies
Description:	Rabbit polyclonal antibody to ErbB-3 (E1218)
Specificity:	ErbB-3 (E1218) pAb detects endogenous levels of ErbB-3 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 1200-1250 of Human ErbB-3.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 148, 185 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778). May also be activated by CSPG5 (PubMed:15358134).
Tissue Specificity:	Epithelial tissues and brain.
Involvement in Disease:	Lethal congenital contracture syndrome 2: A form of lethal congenital contracture syndrome, an autosomal recessive disorder characterized by degeneration of anterior horn neurons, extreme skeletal muscle atrophy, and congenital non-progressive joint contractures (arthrogryposis). The contractures can involve the upper or lower limbs and/or the vertebral column, leading to various degrees of flexion or extension limitations evident at birth. LCCS2 patients manifest craniofacial/ocular findings, lack of hydrops, multiple pterygia, and fractures, as well as a normal duration of pregnancy and a unique feature of a markedly distended urinary bladder (neurogenic bladder defect). The phenotype suggests a spinal cord neuropathic etiology.
Sequence Similarities:	Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.
Post-Translational Modification:	Autophosphorylated (PubMed:20351256). Ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
Cellular locations:	Cell membrane.
Database Links:	Entrez Gene: 2065?Human Entrez Gene: 13867?Mouse Entrez Gene: 29496?Rat Omim: 190151?Human SwissProt: P21860?Human SwissProt: Q61526?Mouse SwissProt: Q62799?Rat Unigene: 118681?Human Unigene: 373043?Mouse Unigene: 10228?Rat
Synonyms:	c erbB 3 Antibody c erbB3 Antibody Erb b2 receptor tyrosine kinase 3 Antibody ErbB 3 Antibody ERBB3 Antibody ERBB3 protein Antibody erbB3 S Antibody ERBB3_HUMAN Antibody Glial growth factor receptor Antibody HER 3 Antibody HER3 Antibody Human epidermal growth factor receptor 3 Antibody LCCS2 Antibody MDA BF 1 Antibody MGC88033 Antibody p180 ErbB3 Antibody p45 sErbB3 Antibody p85 sErbB3 Antibody proto-oncogene-like protein c ErbB 3 Antibody proto-oncogene-like protein c ErbB3 Antibody Proto-oncogene-like protein c-ErbB-3 Antibody Receptor tyrosine protein kinase erbB 3 Antibody Receptor tyrosine protein kinase erbB3 Antibody Receptor tyrosine-protein kinase erbB-3 Antibody Tyrosine kinase type cell surface receptor HER3 Antibody Tyrosine kinase-type cell surface receptor HER3 Antibody v erb b2 avian erythroblastic leukemia viral oncogene homolog 3 Antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 Antibody v erb b2 erythroblastic leukemia viral oncogene homolog 3 (avian) Antibody
Information:	Target information shown above is from the UniProt Consortium.