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Anti-EIF4EBP2 Antibody

品牌：Antibodies

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规格：100µl

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Anti-EIF4EBP2 Antibody

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Overview

Name:	Anti-EIF4EBP2 Antibody See all EIF4EBP2 primary antibodies
Description:	Rabbit polyclonal antibody to EIF4EBP2
Specificity:	The antibody detects endogenous levels of total EIF4EBP2 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Full length fusion protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Repressor of translation initiation involved in synaptic plasticity, learning and memory formation (By similarity). Regulates EIF4E activity by preventing its assembly into the eIF4F complex: hypophosphorylated form of EIF4EBP2 competes with EIF4G1/EIF4G3 and strongly binds to EIF4E, leading to repress translation. In contrast, hyperphosphorylated form dissociates from EIF4E, allowing interaction between EIF4G1/EIF4G3 and EIF4E, leading to initiation of translation (PubMed:25533957). EIF4EBP2 is enriched in brain and acts as a regulator of synapse activity and neuronal stem cell renewal via its ability to repress translation initiation (By similarity). Mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways (By similarity).
Sequence Similarities:	Belongs to the eIF4E-binding protein family.
Post-Translational Modification:	Phosphorylation at Thr-37, Thr-46, Ser-65, Thr-70 and Ser-83 is mediated by MTOR and corresponds to the hyperphosphorylated form: it abolishes binding to EIF4E by inducing folding of intrinsically disordered regions (PubMed:24207126, PubMed:25533957). First phosphorylated at Thr-37 and Thr-46 by MTOR, inducing folding of region encompassing residues from Pro-18 to Arg-62 of into a four-stranded beta-domain that sequesters the helical YXXXXLPhi motif into a partly buried beta-strand, blocking accessibility to EIF4E. Protein phosphorylated at Thr-37 and Thr-46 is however unstable and subsequent phosphorylation at Ser-65, Thr-70 and Ser-83 is required to stabilize the fold, decreasing affinity for EIF4E by a factor of 4000 (PubMed:24207126, PubMed:25533957). Phosphorylated in response to insulin, EGF and PDGF.
Database Links:	Entrez Gene: 1979?Human Omim: 602224?Human SwissProt: Q13542?Human Unigene: 621200?Human Unigene: 730236?Human
Synonyms:	4E-BP2 Antibody 4EBP2 Antibody 4EBP2_HUMAN Antibody eIF4E binding protein 2 Antibody eIF4E-binding protein 2 Antibody eIF4EBP2 Antibody Eukaryotic translation initiation factor 4E binding protein 1 Antibody Eukaryotic translation initiation factor 4E-binding protein 2 Antibody PHASII Antibody phosphorylated, heat and acid stable regulated by insulin protein II Antibody
Information:	Target information shown above is from the UniProt Consortium.