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Anti-EIF3C Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-EIF3C Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-EIF3C Antibody See all EIF3C primary antibodies
Description:	Rabbit polyclonal antibody to EIF3C.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:100.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human EIF3C.
Protein Length:	913
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773, PubMed:27462815). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773).
Sequence Similarities:	Belongs to the eIF-3 subunit C family.
Post-Translational Modification:	Phosphorylated. Phosphorylation is enhanced upon serum stimulation.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 8663?Human Entrez Gene: 56347?Mouse Entrez Gene: 293484?Rat Omim: 603916?Human SwissProt: Q99613?Human SwissProt: Q8R1B4?Mouse SwissProt: B5DFC8?Rat Unigene: 567374?Human Unigene: 22776?Mouse Unigene: 4207?Rat
Synonyms:	Cell migration inducing protein 17 Antibody eIF 3c Antibody eIF3 p110 Antibody eIF3-p110 Antibody eIF3c Antibody EIF3CL Antibody EIF3C_HUMAN Antibody eIF3s8 Antibody EIF3S8 protein Antibody Eukaryotic translation initiation factor 3 subunit 8 Antibody Eukaryotic translation initiation factor 3 subunit 8 (110kD) Antibody Eukaryotic translation initiation factor 3 subunit 8 110kDa Antibody Eukaryotic translation initiation factor 3 subunit C Antibody
Information:	Target information shown above is from the UniProt Consortium.