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Anti-EFP (D222) Antibody

品牌：Antibodies

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规格：50µl

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Anti-EFP (D222) Antibody

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Overview

Name:	Anti-EFP (D222) Antibody See all EFP primary antibodies
Description:	Rabbit polyclonal antibody to EFP (D222)
Specificity:	EFP (D222) pAb detects endogenous levels of EFP protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 360-418 of Human EFP.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 71 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region which is crucial for triggering the cytosolic signal transduction that leads to the production of interferons in response to viral infection. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates estrogen action in various target organs. Mediates the ubiquitination and subsequent proteasomal degradation of ZFHX3 (PubMed:22452784).
Tissue Specificity:	Expressed in breast tumors (at protein level). Ubiquitous.
Post-Translational Modification:	Auto-ISGylated.
Cellular locations:	Cytoplasm. Colocalized with DDX58 at cytoplasmic perinuclear bodies.
Database Links:	Entrez Gene: 7706?Human Entrez Gene: 217069?Mouse Entrez Gene: 494338?Rat Omim: 600453?Human SwissProt: Q14258?Human SwissProt: Q61510?Mouse Unigene: 528952?Human Unigene: 248445?Mouse Unigene: 34382?Rat
Synonyms:	E3 ubiquitin/ISG15 ligase TRIM25 Antibody EFP Antibody Estrogen responsive finger protein Antibody Estrogen-responsive finger protein Antibody RING finger protein 147 Antibody RNF 147 Antibody RNF147 Antibody TRI25 Antibody TRI25_HUMAN Antibody TRIM 25 Antibody TRIM25 Antibody Tripartite motif containing 25 Antibody Tripartite motif containing protein 25 Antibody Tripartite motif protein TRIM25 Antibody Tripartite motif-containing protein 25 Antibody Tripartite motifcontaining25 Antibody Ubiquitin/ISG15-conjugating enzyme TRIM25 Antibody Z147 Antibody Zinc finger protein 147 Antibody Zinc finger protein 147 (estrogen responsive finger protein) Antibody Zinc finger protein-147 Antibody ZNF 147 Antibody ZNF147 Antibody
Information:	Target information shown above is from the UniProt Consortium.