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Anti-DUSP6 Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-DUSP6 Antibody

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Overview

Name:	Anti-DUSP6 Antibody See all DUSP6 primary antibodies
Description:	Rabbit polyclonal antibody to DUSP6
Specificity:	The antibody detects endogenous level of total DUSP6 protein.
Applications:	E, WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein corresponding to a region derived from 206-381 amino acids of human dual specificity phosphatase 6
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Formulation:	Supplied at 0.9mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol.
Storage:	Store at -20?C / 1 year

Target

Function:	Inactivates MAP kinases. Has a specificity for the ERK family (PubMed:9858808). Plays an important role in alleviating chronic postoperative pain. Necessary for the normal dephosphorylation of the long-lasting phosphorylated forms of spinal MAPK1/3 and MAP kinase p38 induced by peripheral surgery, which drives the resolution of acute postoperative allodynia (By similarity).
Involvement in Disease:	Hypogonadotropic hypogonadism 19 with or without anosmia: A disorder characterized by absent or incomplete sexual maturation by the age of 18 years, in conjunction with low levels of circulating gonadotropins and testosterone and no other abnormalities of the hypothalamic-pituitary axis. In some cases, it is associated with non-reproductive phenotypes, such as anosmia, cleft palate, and sensorineural hearing loss. Anosmia or hyposmia is related to the absence or hypoplasia of the olfactory bulbs and tracts. Hypogonadism is due to deficiency in gonadotropin-releasing hormone and probably results from a failure of embryonic migration of gonadotropin-releasing hormone-synthesizing neurons. In the presence of anosmia, idiopathic hypogonadotropic hypogonadism is referred to as Kallmann syndrome, whereas in the presence of a normal sense of smell, it has been termed normosmic idiopathic hypogonadotropic hypogonadism (nIHH).
Sequence Similarities:	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 1848?Human Omim: 602748?Human SwissProt: Q16828?Human Unigene: 298654?Human Unigene: 718640?Human
Synonyms:	Dual specificity phosphatase 6 Antibody Dual specificity phosphatase 6 isoform a Antibody Dual specificity protein phosphatase 6 Antibody Dual specificity protein phosphatase PYST1 Antibody DUS6_HUMAN Antibody DUSP 6 Antibody DUSP 6a Antibody DUSP6 Antibody DUSP6a Antibody HH19 Antibody MAP kinase phosphatase 3 Antibody Mitogen activated protein kinase phosphatase 3 Antibody Mitogen-activated protein kinase phosphatase 3 Antibody MKP 3 Antibody MKP-3 Antibody MKP3 Antibody PYST 1 Antibody PYST1 Antibody Serine/threonine specific protein phosphatase Antibody
Information:	Target information shown above is from the UniProt Consortium.