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Anti-CREB (Ab-133) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CREB (Ab-133) Antibody

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Overview

Name:	Anti-CREB (Ab-133) Antibody See all CREB primary antibodies
Description:	Rabbit polyclonal antibody to CREB (Ab-133)
Specificity:	The antibody detects endogenous level of total CREB protein and it also detects the CREB-related protein ATF-1.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Peptide sequence around aa. 131~135 (R-P-S-Y-R) derived from Human CREB.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration:	1.0mg / ml
Formulation:	Supplied at 1.0mg / mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

Target

Function:	Phosphorylation-dependent transcription factor that stimulates transcription upon binding to the DNA cAMP response element (CRE), a sequence present in many viral and cellular promoters. Transcription activation is enhanced by the TORC coactivators which act independently of Ser-133 phosphorylation. Involved in different cellular processes including the synchronization of circadian rhythmicity and the differentiation of adipose cells.
Involvement in Disease:	Angiomatoid fibrous histiocytoma: A distinct variant of malignant fibrous histiocytoma that typically occurs in children and adolescents and is manifest by nodular subcutaneous growth. Characteristic microscopic features include lobulated sheets of histiocyte-like cells intimately associated with areas of hemorrhage and cystic pseudovascular spaces, as well as a striking cuffing of inflammatory cells, mimicking a lymph node metastasis.
Sequence Similarities:	Belongs to the bZIP family.
Post-Translational Modification:	Stimulated by phosphorylation. Phosphorylation of both Ser-133 and Ser-142 in the SCN regulates the activity of CREB and participates in circadian rhythm generation. Phosphorylation of Ser-133 allows CREBBP binding. In liver, phosphorylation is induced by fasting or glucagon in a circadian fashion (By similarity). CREBL2 positively regulates phosphorylation at Ser-133 thereby stimulating CREB1 transcriptional activity (By similarity). Phosphorylated upon calcium influx by CaMK4 and CaMK2 on Ser-133. CaMK4 is much more potent than CaMK2 in activating CREB. Phosphorylated by CaMK2 on Ser-142. Phosphorylation of Ser-142 blocks CREB-mediated transcription even when Ser-133 is phosphorylated. Phosphorylated by CaMK1 (By similarity). Phosphorylation of Ser-271 by HIPK2 in response to genotoxic stress promotes CREB1 activity, facilitating the recruitment of the coactivator CBP. Phosphorylated at Ser-133 by RPS6KA3, RPS6KA4 and RPS6KA5 in response to mitogenic or stress stimuli.
Cellular locations:	Nucleus.
Database Links:	Entrez Gene: 1385?Human Entrez Gene: 12912?Mouse Omim: 123810?Human SwissProt: P16220?Human SwissProt: Q01147?Mouse Unigene: 516646?Human Unigene: 453295?Mouse
Synonyms:	Active transcription factor CREB Antibody cAMP response element binding protein Antibody cAMP response element binding protein 1 Antibody cAMP responsive element binding protein 1 Antibody cAMP-responsive element-binding protein 1 Antibody CREB Antibody CREB-1 Antibody CREB1 Antibody CREB1_HUMAN Antibody Cyclic AMP-responsive element-binding protein 1 Antibody MGC9284 Antibody OTTHUMP00000163864 Antibody OTTHUMP00000163865 Antibody OTTHUMP00000206660 Antibody OTTHUMP00000206662 Antibody OTTHUMP00000206667 Antibody Transactivator protein Antibody
Information:	Target information shown above is from the UniProt Consortium.