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Anti-Collagen V α2 Antibody

品牌：Antibodies

货号：

规格：50µl

货期：

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Anti-Collagen V α2 Antibody

商品详情参考文献相关资料

Name:	Anti-Collagen V α2 Antibody See all Collagen V α2 primary antibodies
Description:	Rabbit polyclonal antibody to Collagen V α2
Specificity:	The antibody detects endogenous levels of total Collagen V α2 protein.
Applications:	IHC, IF
Reactivity:	Human
Immunogen:	Synthesized peptide derived from internal of human Collagen V α2.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Function:	Type V collagen is a member of group I collagen (fibrillar forming collagen). It is a minor connective tissue component of nearly ubiquitous distribution. Type V collagen binds to DNA, heparan sulfate, thrombospondin, heparin, and insulin. Type V collagen is a key determinant in the assembly of tissue-specific matrices (By similarity).
Involvement in Disease:	Ehlers-Danlos syndrome, classic type: A connective tissue disorder characterized by hyperextensible skin, atrophic cutaneous scars due to tissue fragility and joint hyperlaxity.
Sequence Similarities:	Belongs to the fibrillar collagen family.
Post-Translational Modification:	Prolines at the third position of the tripeptide repeating unit (G-X-P) are hydroxylated in some or all of the chains. Probably 3-hydroxylated on Pro-919 and Pro-1156 by LEPREL1.
Cellular locations:	Secreted > Extracellular space > Extracellular matrix.