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Anti-CIDEA Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-CIDEA Antibody

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Overview

Name:	Anti-CIDEA Antibody See all CIDEA primary antibodies
Description:	Rabbit polyclonal antibody to CIDEA.
Applications:	WB, IF
Dilutions:	WB: 1:500 - 1:2000, IF: 1:50 - 1:100.
Reactivity:	Human
Immunogen:	Recombinant protein of human CIDEA.
Protein Length:	219
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter (By similarity). Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
Tissue Specificity:	Expressed in omental and subcutaneous adipose tissue (at protein level).
Cellular locations:	Lipid droplet. Nucleus. Enriched at lipid droplet contact sites. Has been shown to localize to mitonchondria, where it could interact with UCP1 and hence inhibit UCP1 uncoupling activity (By similarity). These data could not be confirmed (PubMed:18509062).
Database Links:	Entrez Gene: 1149 Human Omim: 604440 Human SwissProt: O60543 Human Unigene: 249129 Human
Synonyms:	Cell death activator CIDE A Antibody Cell Death Inducing DFFA Like Effector A Antibody cell death inducing DNA fragmentation factor, alpha subunit like effector A Antibody CIDE A Antibody CIDE-A Antibody CIDEA Antibody
Information:	Target information shown above is from the UniProt Consortium.