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Anti-CHRM2 Antibody

品牌：Antibodies

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规格：50µl

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Anti-CHRM2 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-CHRM2 Antibody See all CHRM2 primary antibodies
Description:	Rabbit polyclonal antibody to CHRM2.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human CHRM2.
Protein Length:	466
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is adenylate cyclase inhibition. Signaling promotes phospholipase C activity, leading to the release of inositol trisphosphate (IP3); this then triggers calcium ion release into the cytosol.
Involvement in Disease:	Major depressive disorder: A common psychiatric disorder. It is a complex trait characterized by one or more major depressive episodes without a history of manic, mixed, or hypomanic episodes. A major depressive episode is characterized by at least 2 weeks during which there is a new onset or clear worsening of either depressed mood or loss of interest or pleasure in nearly all activities. Four additional symptoms must also be present including changes in appetite, weight, sleep, and psychomotor activity; decreased energy; feelings of worthlessness or guilt; difficulty thinking, concentrating, or making decisions; or recurrent thoughts of death or suicidal ideation, plans, or attempts. The episode must be accompanied by distress or impairment in social, occupational, or other important areas of functioning.
Sequence Similarities:	Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily. CHRM2 sub-subfamily.
Post-Translational Modification:	Phosphorylated in response to agonist treatment.
Cellular locations:	Cell membrane. Cell junction > Synapse > Postsynaptic cell membrane. Phosphorylation in response to agonist binding promotes receptor internalization.
Database Links:	Entrez Gene: 1129?Human Entrez Gene: 243764?Mouse Entrez Gene: 81645?Rat Omim: 118493?Human SwissProt: P08172?Human SwissProt: Q9ERZ4?Mouse SwissProt: P10980?Rat Unigene: 535891?Human Unigene: 448632?Mouse Unigene: 10752?Rat Unigene: 200974?Rat
Synonyms:	7TM receptor Antibody Acetylcholine receptor, muscarinic, 2 Antibody AChR Antibody Acm2 Antibody ACM2_HUMAN Antibody Cholinergic receptor muscarinic 2 Antibody Cholinergic receptor, muscarinic 2, cardiac Antibody Cholinergic receptor, muscarinic 2, isoform a Antibody Cholinergic receptor, muscarinic 2a Antibody CHRM 2 Antibody CHRM2 Antibody chrm2a Antibody CM2 Antibody FLJ43243 Antibody HM 2 Antibody HM2 Antibody M2 Antibody M2 muscarinic receptor Antibody M2-mAChR Antibody MGC120006 Antibody MGC120007 Antibody Muscarinic Acetylcholine Receptor 2 Antibody Muscarinic acetylcholine receptor M2 Antibody Muscarinic M2 receptor Antibody
Information:	Target information shown above is from the UniProt Consortium.