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Anti-CFTR (E733) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CFTR (E733) Antibody

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Overview

Name:	Anti-CFTR (E733) Antibody See all CFTR primary antibodies
Description:	Rabbit polyclonal antibody to CFTR (E733)
Specificity:	CFTR (E733) pAb detects endogenous levels of CFTR protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 700-750 of Human CFTR.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 168 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Involved in the transport of chloride ions. May regulate bicarbonate secretion and salvage in epithelial cells by regulating the SLC4A7 transporter. Can inhibit the chloride channel activity of ANO1. Plays a role in the chloride and bicarbonate homeostasis during sperm epididymal maturation and capacitation.
Tissue Specificity:	Expressed in the respiratory airway, including bronchial epithelium, and in the female reproductive tract, including oviduct (at protein level).
Involvement in Disease:	Cystic fibrosis: A common generalized disorder of the exocrine glands which impairs clearance of secretions in a variety of organs. It is characterized by the triad of chronic bronchopulmonary disease (with recurrent respiratory infections), pancreatic insufficiency (which leads to malabsorption and growth retardation) and elevated sweat electrolytes. It is the most common genetic disease in Caucasians, with a prevalsence of about 1 in 2'000 live births. Inheritance is autosomal recessive. Congenital bilateral absence of the vas deferens: Important cause of sterility in men and could represent an incomplete form of cystic fibrosis, as the majority of men suffering from cystic fibrosis lack the vas deferens.
Sequence Similarities:	Belongs to the ABC transporter superfamily. ABCC family. CFTR transporter (TC 3.A.1.202) subfamily.
Post-Translational Modification:	Phosphorylated; activates the channel. It is not clear whether PKC phosphorylation itself activates the channel or permits activation by phosphorylation at PKA sites. Phosphorylated by AMPK.
Cellular locations:	Early endosome membrane. Cell membrane. In the oviduct and bronchus, detected on the apical side of epithelial cells, but not associated with cilia.
Database Links:	Entrez Gene: 1080?Human Entrez Gene: 12638?Mouse Entrez Gene: 24255?Rat Omim: 602421?Human SwissProt: P13569?Human SwissProt: P26361?Mouse SwissProt: P34158?Rat Unigene: 489786?Human Unigene: 621460?Human Unigene: 661104?Human Unigene: 15621?Mouse Unigene: 124539?Rat
Synonyms:	ABC 35 Antibody ABC35 Antibody ABCC 7 Antibody ABCC7 Antibody ATP binding cassette sub family C member 7 Antibody ATP Binding Cassette Superfamily C Member 7 Antibody ATP binding cassette transporter sub family C member 7 Antibody ATP-binding cassette sub-family C member 7 Antibody cAMP dependent chloride channel Antibody cAMP-dependent chloride channel Antibody CF Antibody CFTR Antibody CFTR/MRP Antibody CFTR_HUMAN Antibody Channel conductance controlling ATPase Antibody Channel conductance-controlling ATPase Antibody Cystic fibrosis transmembrane conductance regulator Antibody Cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub family C, member 7) Antibody Cystic fibrosis transmembrane conductance regulator ATP binding cassette sub family C member 7 Antibody Cystic Fibrosis Transmembrane Regulator Antibody dJ760C5.1 Antibody MRP 7 Antibody MRP7 Antibody TNR CFTR Antibody
Information:	Target information shown above is from the UniProt Consortium.