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Anti-CFH Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-CFH Antibody

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Overview

Name:	Anti-CFH Antibody See all CFH primary antibodies
Description:	Goat polyclonal antibody to CFH.
Applications:	ELISA, WB, IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human CFH (internal region).
Sequence:	C-HLVPDRKKDQYK
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Factor H functions as a cofactor in the inactivation of C3b by factor I and also increases the rate of dissociation of the C3bBb complex (C3 convertase) and the (C3b)NBB complex (C5 convertase) in the alternative complement pathway.
Tissue Specificity:	Expressed by the liver and secreted in plasma.
Involvement in Disease:	Basal laminar drusen: Drusen are extracellular deposits that accumulate below the retinal pigment epithelium on Bruch membrane. Basal laminar drusen refers to an early *****-onset drusen phenotype that shows a pattern of uniform small, slightly raised yellow subretinal nodules randomly scattered in the macula. In later stages, these drusen often become more numerous, with clustered groups of drusen scattered throughout the retina. In time these small basal laminar drusen may expand and ultimately lead to a serous pigment epithelial detachment of the macula that may result in vision loss. Complement factor H deficiency: A disorder that can manifest as several different phenotypes, including asymptomatic, recurrent bacterial infections, and renal failure. Laboratory features usually include decreased serum levels of factor H, complement component C3, and a decrease in other terminal complement components, indicating activation of the alternative complement pathway. It is associated with a number of renal diseases with variable clinical presentation and progression, including membranoproliferative glomerulonephritis and atypical hemolytic uremic syndrome. Hemolytic uremic syndrome atypical 1: An atypical form of hemolytic uremic syndrome. It is a complex genetic disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher death rates and frequent progression to end-stage renal disease. Macular degeneration, age-related, 4: A form of age-related macular degeneration, a multifactorial eye disease and the most common cause of irreversible vision loss in the developed world. In most patients, the disease is manifest as ophthalmoscopically visible yellowish accumulations of protein and lipid that lie beneath the retinal pigment epithelium and within an elastin-containing structure known as Bruch membrane.
Cellular locations:	Secreted.
Database Links:	Entrez Gene: 3075?Human Omim: 134370?Human SwissProt: P08603?Human Unigene: 363396?Human
Synonyms:	adrenomedullin binding protein Antibody age related maculopathy susceptibility 1 Antibody AHUS 1 Antibody AHUS1 Antibody AMBP 1 Antibody AMBP1 Antibody ARMD 4 Antibody ARMD4 Antibody ARMS 1 Antibody ARMS1 Antibody beta 1 H globulin Antibody beta 1H Antibody beta1H Antibody CFAH_HUMAN Antibody CFH Antibody CFHL 3 Antibody CFHL3 Antibody Complement factor H Antibody complement factor H, isoform b Antibody Factor H Antibody factor H like 1 Antibody FH Antibody FHL 1 Antibody FHL1 Antibody H factor 1 Antibody H factor 1 (complement) Antibody H factor 2 (complement) Antibody HF Antibody HF 1 Antibody HF 2 Antibody HF1 Antibody HF2 Antibody HUS Antibody MGC88246 Antibody
Information:	Target information shown above is from the UniProt Consortium.