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Anti-Cerebral 1 (L310) Antibody |产品详情|进口榴莲视频免费观看采购网





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    Anti-Cerebral 1 (L310) Antibody
    品牌:Antibodies
    货号:
    规格:50µl
    货期:

    Anti-Cerebral 1 (L310) Antibody

    商品详情 参考文献 相关资料
    Name: Anti-Cerebral 1 (L310) Antibody
    See all Cerebral 1 primary antibodies
    Description: Rabbit polyclonal antibody to Cerebral 1 (L310)
    Specificity: Cerebral 1 (L310) pAb detects endogenous levels of Cerebral 1 protein.
    Applications: WB, IHC
    Reactivity: Human, Mouse, Rat
    Immunogen: Synthetic peptide, corresponding to amino acids 291-340 of Human Cerebral 1.
    Host: Rabbit
    Clonality: Polyclonal
    Conjugate: Unconjugated
    Molecular Weight: ~ 51 kDa
    Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
    Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
    Function: Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown.
    Sequence Similarities: Belongs to the methyltransferase superfamily. RRP8 family.
    Cellular locations: Nucleus > Nucleolus.

    Localizes at rDNA locus.
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