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Anti-CD63 (8H2) Antibody

品牌：Antibodies

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规格：50µl

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Anti-CD63 (8H2) Antibody

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Overview

Name:	Anti-CD63 (8H2) Antibody See all CD63 primary antibodies
Description:	Mouse monoclonal antibody to CD63 (8H2)
Specificity:	CD63 (8H2) mouse monoclonal antibody detects endogenous levels of CD63 protein
Applications:	WB
Reactivity:	Human, Mouse, Rat
Immunogen:	A synthetic peptide corresponding to residues in Human CD63.
Host:	Mouse
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 25 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 96% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.3.

Target

Function:	Functions as cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli.
Tissue Specificity:	Detected in platelets (at protein level). Dysplastic nevi, radial growth phase primary melanomas, hematopoietic cells, tissue macrophages.
Sequence Similarities:	Belongs to the tetraspanin (TM4SF) family.
Post-Translational Modification:	Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro).
Cellular locations:	Cell membrane. Lysosome membrane. Late endosome membrane. Endosome > Multivesicular body. Melanosome. Secreted > Exosome. Cell surface. Also found in Weibel-Palade bodies of endothelial cells (PubMed:10793155). Located in platelet dense granules (PubMed:7682577). Detected in a subset of pre-melanosomes. Detected on intralumenal vesicles (ILVs) within multivesicular bodies (PubMed:21962903).
Database Links:	Entrez Gene: 967 Human Entrez Gene: 12512 Mouse Entrez Gene: 29186 Rat Omim: 155740 Human SwissProt: P08962 Human SwissProt: P41731 Mouse SwissProt: P28648 Rat Unigene: 445570 Human Unigene: 371552 Mouse Unigene: 416079 Mouse Unigene: 11068 Rat
Synonyms:	Lysosomal associated membrane protein 3 Antibody CD 63 Antibody CD63 Antibody CD63 antigen Antibody CD63 antigen (melanoma 1 antigen) Antibody CD63 antigen melanoma 1 antigen Antibody CD63 molecule Antibody CD63_HUMAN Antibody gp55 Antibody Granulophysin Antibody LAMP 3 Antibody LAMP-3 Antibody LAMP3 Antibody LIMP Antibody Lysosomal-associated membrane protein 3 Antibody Lysosome associated membrane glycoprotein 3 Antibody Mast cell antigen AD1 Antibody ME491 Antibody Melanoma 1 antigen Antibody Melanoma associated antigen ME491 Antibody Melanoma associated antigen MLA1 Antibody Melanoma-associated antigen ME491 Antibody MGC72893 Antibody MLA 1 Antibody MLA1 Antibody NGA Antibody Ocular melanoma associated antigen Antibody Ocular melanoma-associated antigen Antibody OMA81H Antibody PTLGP40 Antibody Tetraspanin 30 Antibody Tetraspanin-30 Antibody Tspan 30 Antibody Tspan-30 Antibody TSPAN30 Antibody
Information:	Target information shown above is from the UniProt Consortium.