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Anti-Cathepsin E (I292) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Cathepsin E (I292) Antibody

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Overview

Name:	Anti-Cathepsin E (I292) Antibody See all Cathepsin E primary antibodies
Description:	Rabbit polyclonal antibody to Cathepsin E (I292)
Specificity:	Cathepsin?E (I292) pAb detects endogenous levels of Cathepsin?E protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 260-310 of Human Cathepsin E.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 48 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	May have a role in immune function. Probably involved in the processing of antigenic peptides during MHC class II-mediated antigen presentation. May play a role in activation-induced lymphocyte depletion in the thymus, and in neuronal degeneration and glial cell activation in the brain.
Tissue Specificity:	Expressed abundantly in the stomach, the Clara cells of the lung and activated B-lymphocytes, and at lower levels in lymph nodes, skin and spleen. Not expressed in resting B-lymphocytes.
Sequence Similarities:	Belongs to the peptidase A1 family.
Post-Translational Modification:	Glycosylated. The nature of the carbohydrate chain varies between cell types. In fibroblasts, the proenzyme contains a high mannose-type oligosaccharide, while the mature enzyme contains a complex-type oligosaccharide. In erythrocyte membranes, both the proenzyme and mature enzyme contain a complex-type oligosaccharide.
Cellular locations:	Endosome. The proenzyme is localized to the endoplasmic reticulum and Golgi apparatus, while the mature enzyme is localized to the endosome.
Database Links:	Entrez Gene: 1510?Human Entrez Gene: 13034?Mouse Entrez Gene: 25424?Rat Omim: 116890?Human SwissProt: P14091?Human SwissProt: P70269?Mouse SwissProt: P16228?Rat Unigene: 644082?Human
Synonyms:	CATE Antibody CATE_HUMAN Antibody Cathepsin E Antibody Cathepsin E form II Antibody CTSE Antibody Erythrocyte membrane aspartic proteinase Antibody Slow moving proteinase Antibody
Information:	Target information shown above is from the UniProt Consortium.