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Anti-Caspase-3 Antibody

品牌：Antibodies

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规格：100µl

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Anti-Caspase-3 Antibody

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Overview

Name:	Anti-Caspase-3 Antibody See all Caspase-3 primary antibodies
Description:	Rabbit polyclonal antibody to Caspase-3
Specificity:	The antibody detects endogenous level of total Caspase-3 polyclonal antibody.
Applications:	WB, IHC
Reactivity:	Human, Mouse
Immunogen:	Recombinant human Caspase-3 protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration:	1.0mg / mL
Formulation:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage:	Store at -20?C

Target

Function:	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-\|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage.
Tissue Specificity:	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Sequence Similarities:	Belongs to the peptidase C14A family.
Post-Translational Modification:	Cleavage by granzyme B, caspase-6, caspase-8 and caspase-10 generates the two active subunits. Additional processing of the propeptides is likely due to the autocatalytic activity of the activated protease. Active heterodimers between the small subunit of caspase-7 protease and the large subunit of caspase-3 also occur and vice versa.
Cellular locations:	Cytoplasm.
Database Links:	Entrez Gene: 836?Human Entrez Gene: 12367?Mouse Omim: 600636?Human SwissProt: P42574?Human SwissProt: P70677?Mouse Unigene: 141125?Human Unigene: 34405?Mouse
Synonyms:	A830040C14Rik Antibody Apopain Antibody CASP-3 Antibody CASP3 Antibody Casp3a Antibody CASP3_HUMAN Antibody Caspase 3 Antibody Caspase 3, apoptosis-related cysteine peptidase Antibody Caspase 3, apoptosis-related cysteine protease Antibody Caspase 3, apoptosis-related cysteine protease a Antibody Caspase-3 Antibody Caspase-3 subunit p12 Antibody CC3 Antibody CPP-32 Antibody CPP32 Antibody CPP32B Antibody Cysteine protease CPP32 Antibody EC 3.4.22.56 Antibody LICE Antibody mldy Antibody OTTHUMP00000165052 Antibody OTTHUMP00000165053 Antibody OTTHUMP00000165054 Antibody PARP cleavage protease Antibody Procaspase3 Antibody Protein Yama Antibody SCA 1 Antibody SCA-1 Antibody SREBP cleavage activity 1 Antibody Yama Antibody
Information:	Target information shown above is from the UniProt Consortium.