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Anti-Bone morphogenetic protein 2 Antibody

品牌：Antibodies

货号：

规格：100µl

货期：

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Anti-Bone morphogenetic protein 2 Antibody

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Name:	Anti-Bone morphogenetic protein 2 Antibody See all Bone morphogenetic protein 2 primary antibodies
Description:	Rabbit polyclonal antibody to Bone morphogenetic protein 2
Specificity:	The antibody detects endogenous level of total Bone morphogenetic protein 2 polyclonal antibody.
Applications:	IHC
Reactivity:	Human
Immunogen:	Recombinant human Bone morphogenetic protein 2 protein
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Caprylic Acid Ammonium Sulfate Precipitation purified
Concentration:	1.0mg / mL
Formulation:	Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Storage:	Store at -20?C

Function:	Induces cartilage and bone formation (PubMed:3201241). Stimulates the differentiation of myoblasts into osteoblasts via the EIF2AK3-EIF2A- ATF4 pathway. BMP2 activation of EIF2AK3 stimulates phosphorylation of EIF2A which leads to increased expression of ATF4 which plays a central role in osteoblast differentiation. In addition stimulates TMEM119, which upregulates the expression of ATF4 (PubMed:24362451).
Tissue Specificity:	Particularly abundant in lung, spleen and colon and in low but significant levels in heart, brain, placenta, liver, skeletal muscle, kidney, pancreas, prostate, ovary and small intestine.
Sequence Similarities:	Belongs to the TGF-beta family.
Cellular locations:	Secreted.