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Anti-BLNK (Phospho-Tyr84) Antibody

品牌：Antibodies

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规格：50µl

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Anti-BLNK (Phospho-Tyr84) Antibody

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Overview

Name:	Anti-BLNK (Phospho-Tyr84) Antibody See all BLNK primary antibodies
Description:	Rabbit polyclonal antibody to BLNK (Phospho-Tyr84)
Specificity:	The antibody detects endogenous levels of BLNK only when phosphorylated at tyrosine 84.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Peptide sequence around phosphorylation site of tyrosine 84 (E-M-Y(p)-V-M) derived from Human BLNK.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates. Antibodies were purified by affinity-chromatography using epitope-specific phosphopeptide. Non-phospho specific antibodies were removed by chromatogramphy using non-phosphopeptide.
Concentration:	1.0mg / ml
Formulation:	Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Storage:	Store at -20?C

Target

Function:	Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca(2+) mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
Tissue Specificity:	Expressed in B-cell lineage and fibroblast cell lines (at protein level). Highest levels of expression in the spleen, with lower levels in the liver, kidney, pancreas, small intestines and colon.
Involvement in Disease:	Agammaglobulinemia 4, autosomal recessive: A primary immunodeficiency characterized by profoundly low or absent serum antibodies and low or absent circulating B-cells due to an early block of B-cell development. Affected individuals develop severe infections in the first years of life.
Post-Translational Modification:	Following BCR activation, phosphorylated on tyrosine residues by SYK and LYN. When phosphorylated, serves as a scaffold to assemble downstream targets of antigen activation, including PLCG1, VAV1, GRB2 and NCK1. Phosphorylation of Tyr-84, Tyr-178 and Tyr-189 facilitates PLCG1 binding. Phosphorylation of Tyr-96 facilitates BTK binding. Phosphorylation of Tyr-72 facilitates VAV1 and NCK1 binding. Phosphorylation is required for both Ca(2+) and MAPK signaling pathways.
Cellular locations:	Cytoplasm. Cell membrane. BCR activation results in the translocations to membrane fraction.
Database Links:	Entrez Gene: 29760?Human Entrez Gene: 17060?Mouse Entrez Gene: 499356?Rat Omim: 604515?Human SwissProt: Q8WV28?Human SwissProt: Q9QUN3?Mouse SwissProt: Q4KM52?Rat Unigene: 665244?Human Unigene: 9749?Mouse Unigene: 32684?Rat
Synonyms:	AGM4 Antibody B cell adapter containing SH2 domain protein Antibody B cell adapter containing Src homology 2 domain protein Antibody B cell adaptor containing SH2 domain Antibody B cell linker Antibody B cell linker protein Antibody B cell-specific adaptor protein Antibody B-cell activation Antibody B-cell adapter containing a SH2 domain protein Antibody B-cell adapter containing a Src homology 2 domain protein Antibody B-cell linker protein Antibody BASH Antibody Bca Antibody BLNK Antibody BLNK s Antibody BLNK_HUMAN Antibody Cytoplasmic adapter protein Antibody Ly 57 Antibody Ly57 Antibody Lymphocyte antigen 57 Antibody Lyw 57 Antibody Lyw57 Antibody MGC111051 Antibody SH2 domain-containing leukocyte protein, 65-KD Antibody SLP 65 Antibody SLP-65 Antibody SLP65 Antibody Src homology 2 domain containing leukocyte protein of 65 kDa Antibody Src homology 2 domain-containing leukocyte protein of 65 kDa Antibody Src homology [SH2] domain-containing leukocyte protein of 65 kD Antibody
Information:	Target information shown above is from the UniProt Consortium.