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Anti-BCHE Antibody

品牌：Antibodies

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规格：50µl

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Anti-BCHE Antibody

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Overview

Name:	Anti-BCHE Antibody See all BCHE primary antibodies
Description:	Rabbit polyclonal antibody to BCHE.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human BCHE.
Protein Length:	602
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Esterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
Tissue Specificity:	Detected in blood plasma (at protein level). Present in most cells except erythrocytes.
Involvement in Disease:	Butyrylcholinesterase deficiency: A metabolic disorder characterized by prolonged apnea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnea varies significantly depending on the extent of the enzyme deficiency.
Sequence Similarities:	Belongs to the type-B carboxylesterase/lipase family.
Post-Translational Modification:	N-glycosylated. No other PTM detected (PubMed:20946535). The major N-glycan structures are of the complex diantennary type with 1 and 2 N-acetylneuraminic acid molecules (Neu5Ac) making up approximately 33% and 47% of the total N-glycans, respectively. Only low amounts of fucosylated diantennary N-glycans are detected (approximately 2%). Triantennary N-glycans with or without fucose amount to approximately 13%, whereas 5% of the total N-glycans are of the oligomannosidic or hybrid type.
Cellular locations:	Secreted.
Database Links:	Entrez Gene: 590?Human Entrez Gene: 12038?Mouse Entrez Gene: 65036?Rat Omim: 177400?Human SwissProt: P06276?Human SwissProt: Q03311?Mouse Unigene: 420483?Human Unigene: 250719?Mouse Unigene: 48791?Rat
Synonyms:	Acylcholine acylhydrolase Antibody BCHE Antibody Butyrylcholine esterase Antibody Butyrylcholinesterase Antibody CHE1 Antibody CHE2 Antibody CHLE_HUMAN Antibody Choline esterase II Antibody Cholinesterase Antibody Cholinesterase (serum) 2 Antibody Cholinesterase 1 Antibody E1 Antibody Pseudocholinesterase Antibody Pseudocholinesterase E1 Antibody
Information:	Target information shown above is from the UniProt Consortium.