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Anti-B-raf Antibody

品牌：Antibodies

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规格：100T

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Anti-B-raf Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-B-raf Antibody See all B-raf primary antibodies
Description:	Rabbit monoclonal (K21-F) antibody to B-raf, V600-E (FITC).
Applications:	FC
Dilutions:	2 - 10 μl per test.
Reactivity:	Human
Host:	Rabbit
Clonality:	Monoclonal
Clone:	K21-F
Isotype:	IgG
Conjugate:	FITC
Product Form:	Liquid
Formulation:	Supplied in Aqueous Buffer Solution with 10mg/ml BSA & 0.05% Sodium Azide.
Storage:	Store undiluted at 4°C, in the dark. Do not freeze.

Target

Function:	Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. As part of the U7 snRNP it is involved in histone 3'-end processing. May indirectly play a role in hair development.
Tissue Specificity:	Widely expressed. In scalp skin, it is present in the hair follicle, the epidermis, and the dermis.
Involvement in Disease:	Hypotrichosis 11: A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT11 is characterized by scanty or absent eyebrows and a highly variable degree of alopecia since birth, ranging from slight thinning of scalp and axillary hair to complete loss of scalp and body hair. Pubic hair remains mainly unaffected.
Sequence Similarities:	Belongs to the snRNP Sm proteins family.
Cellular locations:	Cytoplasm > Cytosol. Nucleus. SMN-mediated assembly into core snRNPs occurs in the cytosol before SMN-mediated transport to the nucleus to be included in spliceosomes.
Database Links:	Entrez Gene: 6635 Human Omim: 128260 Human SwissProt: P62304 Human Unigene: 334612 Human Unigene: 654418 Human
Synonyms:	AL022645 Antibody B raf Antibody B-raf Antibody Braf Antibody C76690 Antibody HYPT11 Antibody RUXE_HUMAN Antibody Sm protein E Antibody Sm-E Antibody Small nuclear ribonucleoprotein E Antibody SmE Antibody snRNP-E Antibody snRNPE Antibody SNRPE Antibody
Information:	Target information shown above is from the UniProt Consortium.