Anti-AURKC Antibody |产品详情|进口榴莲视频免费观看采购网

您好，欢迎来到榴莲视频下载地址入口生物网站！请登录注册

我的订单 | 联系榴莲视频下载地址入口 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA8008APP幸福宝榴莲、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口榴莲视频免费观看、Quidel代理、Swant代理、PBL Assay Science代理

网站首页产品中心代理品牌新闻资讯资源中心关于榴莲视频下载地址入口

所在位置：首页 > 产品中心 > Antibodies > Antibodies产品

订购信息

上海榴莲视频下载地址入口生物科技公司

Tel:400-968-7988 021-33779008

Anti-AURKC Antibody

品牌：Antibodies

货号：

规格：100µg

货期：

应用：

咨询客服

立即购买加入购物车

Anti-AURKC Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-AURKC Antibody See all Aurora C primary antibodies
Description:	Goat polyclonal antibody to AURKC.
Applications:	ELISA, WB
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to Human AURKC (N terminal).
Sequence:	PRAVVQLGKAQP-C
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 µg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosesis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. AURKC phosphorylates the CPC complex subunits BIRC5/survivin and INCENP leading to increased AURKC activity. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228'.
Tissue Specificity:	Isoform 1 and isoform 2 are expressed in testis. Elevated expression levels were seen only in a subset of cancer cell lines such as Hep-G2, Huh-7 and HeLa. Expression is maximum at M phase.
Involvement in Disease:	Spermatogenic failure 5: An infertility disorder caused by spermatogenesis defects. Semen from affected men show close to 100% morphologically abnormal multiflagellar spermatozoa with low motility, oversized irregular heads, and abnormal midpsiece and acrosome.
Sequence Similarities:	Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.
Cellular locations:	Nucleus. Chromosome. Chromosome > Centromere. Cytoplasm > Cytoskeleton > Spindle. Distributes in the condensed chromosomes during prophase to metaphase. After entering anaphase, there is a dissociation from separated chromosomes and a redistribution to midzone microtubules, and finally remains in the midbody during cytokinesis.
Database Links:	Entrez Gene: 6795 Human Omim: 603495 Human SwissProt: Q9UQB9 Human Unigene: 98338 Human
Synonyms:	AURKC Antibody AIE 2 Antibody Aie1 Antibody AIE2 Antibody AIK 3 Antibody AIK3 Antibody ARK 3 Antibody ARK-3 Antibody ARK3 Antibody Aur C Antibody AurC Antibody Aurkc Antibody AURKC_HUMAN Antibody aurora 3 Antibody Aurora C Antibody Aurora kinase C Antibody aurora related kinase 3 Antibody Aurora-related kinase 3 Antibody Aurora/Ipl1 related kinase 3 Antibody Aurora/Ipl1-related kinase 3 Antibody Aurora/Ipl1/Eg2 protein 2 Antibody EC 2.7.11.1 Antibody IPL-1/STK13/Aurora C Antibody Serine threonine protein kinase 13 Antibody serine/threonine kinase 13 (aurora/IPL1 like) Antibody serine/threonine protein kinase aurora C Antibody Serine/threonine-protein kinase 13 Antibody Serine/threonine-protein kinase aurora-C Antibody SPGF5 Antibody STK13 Antibody
Information:	Target information shown above is from the UniProt Consortium.