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Anti-SDCBP Antibody

品牌：Antibodies

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规格：100µl

货期：

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Anti-SDCBP Antibody

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Overview

Name:	Anti-SDCBP Antibody See all SDCBP primary antibodies
Description:	Rabbit polyclonal antibody to SDCBP
Specificity:	The antibody detects endogenous levels of total SDCBP protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Full length fusion protein of human SDCBP
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	2.2mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Multifunctional adapter protein involved in diverse array of functions including trafficking of transmembrane proteins, neuro and immunomodulation, exosome biogenesis, and tumorigenesis (PubMed:26291527). Positively regulates TGFB1-mediated SMAD2/3 activation and TGFB1-induced epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types. May increase TGFB1 signaling by enhancing cell-surface expression of TGFR1 by preventing the interaction between TGFR1 and CAV1 and subsequent CAV1-dependent internalization and degradation of TGFR1 (PubMed:25893292). In concert with SDC1/4 and PDCD6IP, regulates exosome biogenesis (PubMed:22660413). Regulates migration, growth, proliferation, and cell cycle progression in a variety of cancer types (PubMed:26539120). In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA) (PubMed:11498591). May also play a role in vesicular trafficking (PubMed:11179419). Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway (PubMed:10230395).
Tissue Specificity:	Expressed in lung cancers, including adenocarcinoma, squamous cell carcinoma and small-cell carcinoma (at protein level) (PubMed:25893292). Widely expressed. Expressed in fetal kidney, liver, lung and brain. In ***** highest expression in heart and placenta.
Post-Translational Modification:	Phosphorylated on tyrosine residues.
Cellular locations:	Cell junction > Focal adhesion. Cell junction > Adherens junction. Cell membrane. Endoplasmic reticulum membrane. Nucleus. Melanosome. Cytoplasm > Cytosol. Cytoplasm > Cytoskeleton. Secreted > Exosome. Membrane raft. Mainly membrane-associated. Localized to adherens junctions, focal adhesions and endoplasmic reticulum. Colocalized with actin stress fibers. Also found in the nucleus. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. Associated to the plasma membrane in the presence of FZD7 and phosphatidylinositol 4,5-bisphosphate (PIP2) (PubMed:27386966).
Database Links:	Entrez Gene: 6386?Human Omim: 602217?Human SwissProt: O00560?Human Unigene: 200804?Human
Synonyms:	MDA-9 Antibody MDA9 Antibody Melanoma differentiation-associated protein 9 Antibody Pro-TGF-alpha cytoplasmic domain-interacting protein 18 Antibody Scaffold protein Pbp1 Antibody SDCB1_HUMAN Antibody SDCBP Antibody ST1 Antibody SYCL Antibody Syndecan binding protein (syntenin) Antibody Syndecan binding protein 1 Antibody Syndecan-binding protein 1 Antibody Syntenin Antibody Syntenin 1 Antibody Syntenin-1 Antibody TACIP18 Antibody
Information:	Target information shown above is from the UniProt Consortium.