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Anti-SEPN1 Antibody

品牌：Antibodies

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规格：100µl

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Anti-SEPN1 Antibody

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Overview

Name:	Anti-SEPN1 Antibody See all SEPN1 primary antibodies
Description:	Rabbit polyclonal antibody to SEPN1
Specificity:	The antibody detects endogenous levels of total SEPN1 protein.
Applications:	IHC
Reactivity:	Human
Immunogen:	Synthetic peptide corresponding to a region derived from internal residues of human selenoprotein N, 1
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	0.5mg / ml
Formulation:	Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol.
Storage:	Store at -20?C

Target

Function:	Isoform 2: Plays an important role in cell protection against oxidative stress and in the regulation of redox-related calcium homeostasis. Regulates the calcium level of the ER by protecting the calcium pump ATP2A2 against the oxidoreductase ERO1A-mediated oxidative damage. Within the ER, ERO1A activity increases the concentration of H(2)O(2), which attacks the luminal thiols in ATP2A2 and thus leads to cysteinyl sulfenic acid formation (-SOH) and SEPN1 reduces the SOH back to free thiol (-SH), thus restoring ATP2A2 activity (PubMed:25452428). Acts as a modulator of ryanodine receptor (RyR) activity: protects RyR from oxidation due to increased oxidative stress, or directly controls the RyR redox state, regulating the RyR-mediated calcium mobilization required for normal muscle development and differentiation (PubMed:19557870, PubMed:18713863).
Tissue Specificity:	Isoform 1 and isoform 2 are expressed in skeletal muscle, brain, lung and placenta. Isoform 2 is also expressed in heart, diaphragm and stomach.
Involvement in Disease:	Rigid spine muscular dystrophy 1: A neuromuscular disorder characterized by poor axial muscle strength, scoliosesis and neck weakness, and a variable degree of spinal rigidity. Early ventilatory insufficiency can lead to death by respiratory failure. Myopathy, congenital, with fiber-type disproportion: A genetically heterogeneous disorder in which there is relative hypotrophy of type 1 muscle fibers compared to type 2 fibers on skeletal muscle biopsy. However, these findings are not specific and can be found in many different myopathic and neuropathic conditions.
Post-Translational Modification:	Isoform 2: N-glycosylated.
Cellular locations:	Endoplasmic reticulum membrane.
Database Links:	Entrez Gene: 57190?Human Omim: 606210?Human SwissProt: Q9NZV5?Human Unigene: 323396?Human
Synonyms:	CFTD Antibody MDRS1 Antibody RSMD1 Antibody RSS Antibody Selenoprotein N Antibody Selenoprotein N, 1 Antibody SelN Antibody SELN_HUMAN Antibody SEPN1 Antibody
Information:	Target information shown above is from the UniProt Consortium.