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Anti-RNF40 Antibody

品牌：Antibodies

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规格：100µl

货期：

应用：

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Anti-RNF40 Antibody

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Overview

Name:	Anti-RNF40 Antibody See all RNF40 primary antibodies
Description:	Rabbit polyclonal antibody to RNF40
Specificity:	The antibody detects endogenous levels of total RNF40 protein.
Applications:	WB, IHC
Reactivity:	Human
Immunogen:	Fusion protein of human RNF40
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Purification:	Antigen affinity purification.
Concentration:	1.3mg / ml
Formulation:	Rabbit IgG in pH7.4 PBS, 0.05% NaN3, 40% Glycerol.
Storage:	Store at -20?C

Target

Function:	Component of the RNF20/40 E3 ubiquitin-protein ligase complex that mediates monoubiquitination of 'Lys-120' of histone H2B (H2BK120ub1). H2BK120ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for histone H3 'Lys-4' and 'Lys-79' methylation (H3K4me and H3K79me, respectively). It thereby plays a central role in histone code and gene regulation. The RNF20/40 complex forms a H2B ubiquitin ligase complex in cooperation with the E2 enzyme UBE2A or UBE2B; reports about the cooperation with UBE2E1/UBCH are contradictory. Required for transcriptional activation of Hox genes.
Tissue Specificity:	Ubiquitously expressed. Expressed at higher level in testis, heart and pancreas, while it is only weakly expressed in lung, skeletal muscle and small intestine.
Sequence Similarities:	Belongs to the BRE1 family.
Cellular locations:	Nucleus.
Database Links:	Entrez Gene: 9810?Human Omim: 607700?Human SwissProt: O75150?Human Unigene: 65238?Human
Synonyms:	95 kDa retinoblastoma associated protein Antibody 95 kDa retinoblastoma protein binding protein Antibody 95 kDa retinoblastoma-associated protein Antibody BRE 1B Antibody BRE1 B Antibody BRE1 E3 ubiquitin ligase homolog B Antibody BRE1-B Antibody BRE1B Antibody BRE1B_HUMAN Antibody DKFZp686K191 Antibody E3 ubiquitin protein ligase BRE1B Antibody E3 ubiquitin-protein ligase BRE1B Antibody KIAA0661 Antibody MGC13051 Antibody Rb associated protein Antibody RBP 95 Antibody RBP95 Antibody RING finger protein 40 Antibody Ring finger protein 40 E3 ubiquitin protein ligase Antibody RNF 40 Antibody RNF40 Antibody STARING Antibody
Information:	Target information shown above is from the UniProt Consortium.