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 Anti-E2F-1 (D426) Antibody |产品详情|进口榴莲视频免费观看采购网





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    Anti-E2F-1 (D426) Antibody
    品牌:Antibodies
    货号:
    规格:50µl
    货期:

    Anti-E2F-1 (D426) Antibody

    商品详情 参考文献 相关资料
    Name: Anti-E2F-1 (D426) Antibody
    See all E2F-1 primary antibodies
    Description: Rabbit polyclonal antibody to E2F-1 (D426)
    Specificity: E2F1 (D426) pAb detects endogenous levels of E2F1 protein.
    Applications: WB, IHC
    Reactivity: Human, Mouse, Rat
    Immunogen: Synthetic peptide, corresponding to amino acids 400-450 of Human E2F-1.
    Host: Rabbit
    Clonality: Polyclonal
    Conjugate: Unconjugated
    Molecular Weight: ~ 47 kDa
    Purity: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
    Product Form: 1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.
    Function: Transcription activator that binds DNA cooperatively with DP proteins through the E2 recognition site, 5'-TTTC[CG]CGC-3' found in the promoter region of a number of genes whose products are involved in cell cycle regulation or in DNA replication. The DRTF1/E2F complex functions in the control of cell-cycle progression from G1 to S phase. E2F1 binds preferentially RB1 in a cell-cycle dependent manner. It can mediate both cell proliferation and TP53/p53-dependent apoptosis. Blocks adipocyte differentiation by binding to specific promoters repressing CEBPA binding to its target gene promoters (PubMed:20176812).
    Sequence Similarities: Belongs to the E2F/DP family.
    Post-Translational Modification: Phosphorylated by CDK2 and cyclin A-CDK2 in the S-phase. Phosphorylation at Ser-364 by CHEK2 stabilizes E2F1 upon DNA damage and regulates its effect on transcription and apoptosis.
    Cellular locations: Nucleus.
    Database Links:
  1. Entrez Gene: 1869?Human
  2. Entrez Gene: 13555?Mouse
  3. Entrez Gene: 399489?Rat
  4. Omim: 189971?Human
  5. SwissProt: Q01094?Human
  6. SwissProt: Q61501?Mouse
  7. SwissProt: O09139?Rat
  8. Unigene: 654393?Human
  9. Unigene: 18036?Mouse
  10. Unigene: 72471?Rat
  11. Synonyms:
  12. DmelCG6376 Antibody
  13. Dmel_CG6376 Antibody
  14. drosE2F1 Antibody
  15. E(Sev-CycE)3A Antibody
  16. E(var)3-93E Antibody
  17. E2-promoter binding facto Antibody
  18. E2F 1 Antibody
  19. E2F transcription factor 1 Antibody
  20. E2F-1 Antibody
  21. E2f-PA Antibody
  22. E2f-PB Antibody
  23. E2f-PC Antibody
  24. E2F1 Antibody
  25. E2f1 E2F transcription factor 1 Antibody
  26. E2F1_HUMAN Antibody
  27. Evar(3)164 Antibody
  28. KIAA4009 Antibody
  29. l(3)07172 Antibody
  30. l(3)j3B1 Antibody
  31. l(3)j3C2 Antibody
  32. l(3)rM729 Antibody
  33. mKIAA4009 Antibody
  34. OTTHUMP00000030661 Antibody
  35. PBR3 Antibody
  36. PRB binding protein E2F 1 Antibody
  37. PRB-binding protein E2F-1 Antibody
  38. RBAP 1 Antibody
  39. RBAP-1 Antibody
  40. RBAP1 Antibody
  41. RBBP-3 Antibody
  42. RBBP3 Antibody
  43. RBP 3 Antibody
  44. RBP3 Antibody
  45. Retinoblastoma-associated protein 1 Antibody
  46. Retinoblastoma-binding protein 3 Antibody
  47. Transcription factor E2F1 Antibody
  48. Information: Target information shown above is from the UniProt Consortium.
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