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Anti-TfR1 (Y20) Antibody

品牌：Antibodies

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规格：50µl

货期：

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Anti-TfR1 (Y20) Antibody

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Overview

Name:	Anti-TfR1 (Y20) Antibody See all TfR1 primary antibodies
Description:	Rabbit polyclonal antibody to TfR1 (Y20)
Specificity:	TfR1 (Y20) pAb detects endogenous levels of TfR1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to the N-terminus of Human TfR1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 89 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal . Positively regulates T and B cell proliferation through iron uptake (PubMed:26642240).
Involvement in Disease:	Immunodeficiency 46: An autosomal recessive primary immunodeficiency disorder characterized by early-onset chronic diarrhea, recurrent infections, hypo- or agammaglobulinemia, normal lymphocyte counts, intermittent neutropenia, and intermittent thrombocytopenia.
Sequence Similarities:	Belongs to the peptidase M28 family. M28B subfamily.
Post-Translational Modification:	N- and O-glycosylated, phosphorylated and palmitoylated. The serum form is only glycosylated.
Cellular locations:	Cell membrane. Melanosome. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
Database Links:	Entrez Gene: 7037?Human Entrez Gene: 22042?Mouse Entrez Gene: 64678?Rat Omim: 190010?Human SwissProt: P02786?Human SwissProt: Q62351?Mouse SwissProt: Q99376?Rat Unigene: 529618?Human Unigene: 28683?Mouse Unigene: 98672?Rat
Synonyms:	CD 71 Antibody CD71 Antibody CD71 antigen Antibody IMD46 Antibody OTTHUMP00000208523 Antibody OTTHUMP00000208524 Antibody OTTHUMP00000208525 Antibody p90 Antibody sTfR Antibody T9 Antibody TfR Antibody TFR 1 Antibody TfR1 Antibody TFR1_HUMAN Antibody TFRC Antibody TR Antibody Transferrin Receptor Antibody Transferrin receptor (p90 CD71) Antibody Transferrin receptor protein 1, serum form Antibody Trfr Antibody
Information:	Target information shown above is from the UniProt Consortium.