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Anti-NF-kB p65 Antibody

品牌：Antibodies

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规格：50µl

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Anti-NF-kB p65 Antibody

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Overview

Name:	Anti-NF-kB p65 Antibody See all NF-kB p65 primary antibodies
Description:	Rabbit monoclonal antibody to NF-kB p65
Specificity:	This antibody detects endogenous levels of NF-kB p65 and does not cross-react with related proteins.
Applications:	WB, ICC/IF, IHC, FC
Reactivity:	Human, Mouse, Zebrafish
Immunogen:	Recombinant antibody.
Host:	Rabbit
Clonality:	Monoclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 65 kDa
Purity:	Protein A affinity purified
Product Form:	Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.

Target

Function:	NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52 and the heterodimeric p65-p50 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. NF-kappa-B heterodimeric p65-p50 and p65-c-Rel complexes are transcriptional activators. The NF-kappa-B p65-p65 complex appears to be involved in invasin-mediated activation of IL-8 expression. The inhibitory effect of I-kappa-B upon NF-kappa-B the cytoplasm is exerted primarily through the interaction with p65. p65 shows a weak DNA- which could contribute directly to DNA binding in the NF-kappa-B complex. Associates with chromatin at the NF-kappa-B promoter region via association with DDX1. Essential for cytokine gene expression in T-cells (PubMed:15790681).
Post-Translational Modification:	Ubiquitinated, leading to its proteasomal degradation. Degradation is required for termination of NF-kappa-B response.
Cellular locations:	Nucleus. Cytoplasm. Colocalized with DDX1 in the nucleus upon TNF-alpha induction (By similarity). Nuclear, but also found in the cytoplasm in an inactive form complexed to an inhibitor (I-kappa-B). Colocalizes with GFI1 in the nucleus after LPS stimulation.
Database Links:	Entrez Gene: 5970?Human Entrez Gene: 19697?Mouse Omim: 164014?Human SwissProt: Q04206?Human SwissProt: Q04207?Mouse Unigene: 502875?Human Unigene: 249966?Mouse
Synonyms:	Avian reticuloendotheliosesis viral (v rel) oncogene homolog A Antibody MGC131774 Antibody NF kappa B p65delta3 Antibody NF-kB p65 Antibody NFKB3 Antibody Nuclear Factor NF Kappa B p65 Subunit Antibody Nuclear factor NF-kappa-B p65 subunit Antibody Nuclear factor of kappa light polypeptide gene enhancer in B cells 3 Antibody Nuclear factor of kappa light polypeptide gene enhancer in B-cells 3 Antibody OTTHUMP00000233473 Antibody OTTHUMP00000233474 Antibody OTTHUMP00000233475 Antibody OTTHUMP00000233476 Antibody OTTHUMP00000233900 Antibody p65 Antibody p65 NF kappaB Antibody p65 NFkB Antibody relA Antibody TF65_HUMAN Antibody Transcription factor p65 Antibody V rel avian reticuloendotheliosesis viral oncogene homolog A Antibody v rel avian reticuloendotheliosesis viral oncogene homolog A (nuclear factor of kappa light polypeptide gene enhancer in B cells 3 (p65)) Antibody v rel reticuloendotheliosesis viral oncogene homolog A (avian) Antibody V rel reticuloendotheliosesis viral oncogene homolog A, nuclear factor of kappa light polypeptide gene enhancer in B cells 3, p65 Antibody
Information:	Target information shown above is from the UniProt Consortium.