| Function: |
Small heat shock protein which functions as a molecular chaperone probably maintaining denatured proteins in a folding-competent state (PubMed:10383393, PubMed:20178975). Plays a role in stress resistance and actin organization (PubMed:19166925). Through its molecular chaperone activity may regulate numerous biological processes including the phosphorylation and the axonal transport of neurofilament proteins (PubMed:23728742). |
| Tissue Specificity: |
Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. |
| Involvement in Disease: |
Charcot-Marie-Tooth disease 2F: A dominant axonal form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Neuropathies of the CMT2 group are characterized by signs of axonal degeneration in the absence of obvious myelin alterations, normal or slightly reduced nerve conduction velocities, and progressive distal muscle weakness and atrophy. Nerve conduction velocities are normal or slightly reduced. Onset of Charcot-Marie-Tooth disease type 2F is between 15 and 25 years with muscle weakness and atrophy usually beginning in feet and legs (peroneal distribution). Upper limb involvement occurs later.
Neuronopathy, distal hereditary motor, 2B: A neuromuscular disorder. Distal hereditary motor neuronopathies constitute a heterogeneous group of neuromuscular disorders caused by selective degeneration of motor neurons in the anterior horn of the spinal cord, without sensory deficit in the posterior horn. The overall clinical picture consists of a classical distal muscular atrophy syndrome in the legs without clinical sensory loss. The disease starts with weakness and wasting of distal muscles of the anterior tibial and peroneal compartments of the legs. Later on, weakness and atrophy may expand to the proximal muscles of the lower limbs and/or to the distal upper limbs. |
| Sequence Similarities: |
Belongs to the small heat shock protein (HSP20) family. |
| Post-Translational Modification: |
Phosphorylated upon exposure to protein kinase C activators and heat shock (PubMed:8325890). Phosphorylation by MAPKAPK2 and MAPKAPK3 in response to stress dissociates HSPB1 from large small heat-shock protein (sHsps) oligomers and impairs its chaperone activity and ability to protect against oxidative stress effectively. Phosphorylation by MAPKAPK5 in response to PKA stimulation induces F-actin rearrangement (PubMed:1332886, PubMed:8093612, PubMed:19166925). |
| Cellular locations: |
Cytoplasm. Nucleus. Cytoplasm > Cytoskeleton > Spindle.
Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| Database Links: |
Entrez Gene: 3315?HumanEntrez Gene: 15507?MouseEntrez Gene: 24471?RatOmim: 602195?HumanSwissProt: P04792?HumanSwissProt: P14602?MouseSwissProt: P42930?RatUnigene: 520973?HumanUnigene: 13849?MouseUnigene: 3841?Rat |
| Synonyms: |
Heat shock 27kDa protein Antibody28 kDa heat shock protein AntibodyCMT2F AntibodyDKFZp586P1322 Antibodyepididymis secretory protein Li 102 AntibodyEstrogen regulated 24 kDa protein AntibodyEstrogen-regulated 24 kDa protein AntibodyHeat shock 25kDa protein 1 AntibodyHeat shock 27 kDa protein AntibodyHeat shock 27kD protein 1 AntibodyHeat shock 27kDa protein 1 AntibodyHeat shock 28kDa protein 1 AntibodyHeat Shock Protein 27 AntibodyHeat shock protein beta 1 AntibodyHeat shock protein beta-1 Antibodyheat shock protein family B (small) member 1 AntibodyHEL-S-102 AntibodyHMN2B AntibodyHS.76067 AntibodyHsp 25 AntibodyHSP 27 AntibodyHsp 28 AntibodyHsp B1 AntibodyHsp25 AntibodyHsp27 AntibodyHsp28 AntibodyHspB1 AntibodyHSPB1_HUMAN AntibodySRP27 AntibodyStress responsive protein 27 AntibodyStress-responsive protein 27 Antibody |
| Information: |
Target information shown above is from the UniProt Consortium. |
