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Anti-PHD1 Antibody |产品详情|进口榴莲视频免费观看采购网


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    Anti-PHD1 Antibody
    品牌：Antibodies
    货号：
    规格：50µl
    货期：

    Anti-PHD1 Antibody
    商品详情 参考文献 相关资料
    Name: Anti-PHD1 Antibody
    See all PHD1 primary antibodies
    Description: Rabbit monoclonal antibody to PHD1
    Specificity: This antibody detects endogenous levels of PHD1 and does not cross-react with related proteins.
    Applications: WB, ICC/IF, IHC, FC
    Reactivity: Human, Mouse, Rat
    Immunogen: Recombinant antibody.
    Host: Rabbit
    Clonality: Monoclonal
    Conjugate: Unconjugated
    Molecular Weight: ~ 44 kDa
    Purity: Protein A affinity purified
    Product Form: Recombinant Rabbit Monoclonal Antibody. 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide.
    Function: Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocations to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. EGLN2 is involved in regulating hypoxia tolerance and apoptosis in cardiac and skeletal muscle. Also regulates susceptibility to normoxic oxidative neuronal death. Links oxygen sensing to cell cycle and primary cilia formation by hydroxylating the critical centrosome component CEP192 which promotes its ubiquitination and subsequent proteasomal degradation. Hydroxylates IKBKB, mediating NF-kappaB activation in hypoxic conditions. Target proteins are preferentially recognized via a LXXLAP motif.
    Tissue Specificity: Expressed in ***** and fetal heart, brain, liver, lung, skeletal muscle, and kidney. Also expressed in testis and placenta. Highest levels in ***** brain, placenta, lung, kidney, and testis. Expressed in hormone responsive tissues, including normal and cancerous mammary, ovarian and prostate epithelium.
    Cellular locations: Nucleus.
    Database Links:
  2. Entrez Gene: 112398?Human
  3. Entrez Gene: 112406?Mouse
  4. Entrez Gene: 308457?Rat
  5. Omim: 606424?Human
  6. SwissProt: Q96KS0?Human
  7. SwissProt: Q91YE2?Mouse
  8. SwissProt: Q6AYU4?Rat
  9. Unigene: 515417?Human
  10. Unigene: 29978?Mouse
  11. Unigene: 43384?Rat
    		12.
    Synonyms:
  12. DKFZp434E026 Antibody
  13. EGL nine (C.elegans) homolog 2 Antibody
  14. Egl nine homolog 2 Antibody
  15. Egl nine homolog 2 (C. elegans) Antibody
  16. EGLN 2 Antibody
  17. EGLN2 Antibody
  18. EGLN2_HUMAN Antibody
  19. EIT 6 Antibody
  20. EIT6 Antibody
  21. Estrogen-induced tag 6 Antibody
  22. HIF P4H 1 Antibody
  23. HIF PH1 Antibody
  24. HIF prolyl hydroxylase 1 Antibody
  25. HIF-PH1 Antibody
  26. HIF-prolyl hydroxylase 1 Antibody
  27. HIFPH 1 Antibody
  28. HIFPH1 Antibody
  29. HPH 3 Antibody
  30. HPH-1 Antibody
  31. HPH-3 Antibody
  32. HPH3 Antibody
  33. Hypoxia inducible factor prolyl hydroxylase 1 Antibody
  34. Hypoxia-inducible factor prolyl hydroxylase 1 Antibody
  35. P4H1 Antibody
  36. PHD 1 Antibody
  37. PhD1 Antibody
  38. PHD1/prolyl hydroxylase Antibody
  39. prolyl hydroxylase domain containing protein 1 Antibody
  40. Prolyl hydroxylase domain-containing protein 1 Antibody
    		41.
    Information: Target information shown above is from the UniProt Consortium.
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