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Anti-DDX5 Antibody

品牌：Antibodies

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规格：50µl

货期：

应用：

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Anti-DDX5 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-DDX5 Antibody See all DDX5 primary antibodies
Description:	Rabbit polyclonal antibody to DDX5.
Applications:	WB, IHC, IF
Dilutions:	WB: 1:500 - 1:2000, IHC: 1:50 - 1:200, IF: 1:50 - 1:200.
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant protein of human DDX5.
Protein Length:	614
Host:	Rabbit
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Affinity purification.
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 50% Glycerol.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Involved in the alternative regulation of pre-mRNA splicing; its RNA helicase activity is necessary for increasing tau exon 10 inclusion and occurs in a RBM4-dependent manner. Binds to the tau pre-mRNA in the stem-loop region downstream of exon 10. The rate of ATP hydrolysis is highly stimulated by single-stranded RNA. Involved in transcriptional regulation; the function is independent of the RNA helicase activity. Transcriptional coactivator for estrogen receptor ESR1 and androgen receptor AR. Increases ESR1 AF-1 domain-mediated transactivation and ESR1 AF-1 and AF-2 domains transcriptional synergistic activity. Synergizes with DDX17 and SRA1 RNA to activate MYOD1 transcriptional activity and involved in skeletal muscle differentiation. Transcriptional coactivator for p53/TP53 and involved in p53/TP53 transcriptional response to DNA damage and p53/TP53-dependent apoptosis. Transcriptional coactivator for RUNX2 and involved in regulation of osteoblast differentiation. Acts as transcriptional repressor in a promoter-specific manner; the function probably involves association with histone deacetylases, such as HDAC1. As component of a large PER complex is involved in the inhibition of 3' transcriptional termination of circadian target genes such as PER1 and NR1D1 and the control of the circadian rhythms.
Sequence Similarities:	Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.
Post-Translational Modification:	Arg-502 is dimethylated, probably to asymmetric dimethylarginine.
Cellular locations:	Nucleus > Nucleolus.
Database Links:	Entrez Gene: 1655?Human Entrez Gene: 13207?Mouse Entrez Gene: 287765?Rat Omim: 180630?Human SwissProt: P17844?Human SwissProt: Q61656?Mouse Unigene: 279806?Human Unigene: 220038?Mouse Unigene: 162208?Rat
Synonyms:	ATP dependent RNA helicase DDX5 Antibody DDX 5 Antibody DDX5 Antibody DDX5_HUMAN Antibody DEAD (Asp Glu Ala Asp) box helicase 5 Antibody DEAD (Asp Glu Ala Asp) box polypeptide 5 Antibody DEAD box 5 Antibody DEAD box protein 5 Antibody DEAD/H (Asp Glu Ala Asp/His) box polypeptide 5 (RNA helicase, 68kD) Antibody G17P1 Antibody HELR Antibody HLR1 Antibody HUMP68 Antibody P68 Antibody p68 RNA helicase Antibody Probable ATP dependent RNA helicase DDX5 Antibody Probable ATP-dependent RNA helicase DDX5 Antibody RNA helicase p68 Antibody
Information:	Target information shown above is from the UniProt Consortium.