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Anti-CD18 Antibody

品牌：Antibodies

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规格：100µg

货期：

应用：

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Anti-CD18 Antibody

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Overview

Name:	Anti-CD18 Antibody See all CD18 primary antibodies
Description:	Mouse monoclonal (MEM-48) antibody to CD18.
Specificity:	The antibody MEM-48 recognizes an epitope involving residues 534-546 in cysteine-rich repeat 3 of the CD18 antigen (integrin beta2 subunit; beta2 integrin). CD18 is a 90-95 kDa type I transmembrane protein expressed on all leukocytes.
Applications:	FC, IP, WB, IHC-P, IHC-Fr, FUNC
Reactivity:	Human
Immunogen:	Leukocytes from a patient suffering from a LGL Type leukemia.
Host:	Mouse
Clonality:	Monoclonal
Clone:	MEM-48
Isotype:	IgG1
Conjugate:	Unconjugated
Purification:	Protein A chromatography.
Concentration:	1 mg/ml
Purity:	> 95% (by SDS-PAGE)
Product Form:	Liquid
Formulation:	Supplied in Phosphate Buffered Saline, pH 7.4, with 15mM Sodium Azide.
Storage:	Store at 2-8°C.

Target

Function:	Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are receptors for the iC3b fragment of the third complement component and for fibrinogen. Integrin alpha-X/beta-2 recognizes the sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2 recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1. Contributes to natural killer cell cytotoxicity (PubMed:15356110). Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992). Triggers neutrophil transmigration during lung injury through PTK2B/PYK2-mediated activation (PubMed:18587400). Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590).
Tissue Specificity:	Leukocytes.
Involvement in Disease:	Leukocyte adhesion deficiency 1: LAD1 patients have recurrent bacterial infections and their leukocytes are deficient in a wide range of adhesion-dependent functions.
Sequence Similarities:	Belongs to the integrin beta chain family.
Post-Translational Modification:	Both Ser-745 and Ser-756 become phosphorylated when T-cells are exposed to phorbol esters (PubMed:11700305). Phosphorylation on Thr-758 (but not on Ser-756) allows interaction with 14-3-3 proteins (PubMed:11700305, PubMed:16301335).
Cellular locations:	Membrane.
Database Links:	Entrez Gene: 3689?Human Omim: 600065?Human SwissProt: P05107?Human Unigene: 375957?Human
Synonyms:	95 subunit beta Antibody Beta 2 (antigen CD18 (p95) Antibody CD 18 Antibody CD18 Antibody Cell surface adhesion glycoprotein LFA 1/CR3/P150,959 beta subunit precursor) Antibody Cell surface adhesion glycoproteins LFA 1/CR3/p150,95 subunit beta Antibody Cell surface adhesion glycoproteins LFA-1/CR3/p150 Antibody Complement component 3 receptor 3 and 4 subunit Antibody Complement receptor C3 beta subunit Antibody Complement receptor C3 subunit beta Antibody Integrin beta 2 Antibody Integrin beta chain beta 2 Antibody Integrin beta-2 Antibody Integrin beta-2 (ITGB2) Antibody Integrin, beta 2 (complement component 3 receptor 3 and 4 subunit) Antibody ITB2_HUMAN Antibody ITGB2 Antibody LAD Antibody LCAMB Antibody Leukocyte associated antigens CD18/11A, CD18/11B, CD18/11C Antibody Leukocyte cell adhesion molecule CD18 Antibody LFA 1 Antibody LFA1 Antibody Lymphocyte function associated antigen 1 Antibody Lymphocyte function associated antigen 1 (LFA1) Antibody MAC 1 Antibody MAC1 Antibody Macrophage antigen 1 (mac1) beta Antibody MF17 Antibody MFI7 Antibody OTTHUMP00000115278 Antibody OTTHUMP00000115279 Antibody OTTHUMP00000115280 Antibody OTTHUMP00000115281 Antibody OTTHUMP00000115282 Antibody
Information:	Target information shown above is from the UniProt Consortium.