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Anti-IL-6 Antibody

品牌：Antibodies

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规格：50µl

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Anti-IL-6 Antibody

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Overview

Name:	Anti-IL-6 Antibody See all IL-6 primary antibodies
Description:	Rabbit polyclonal antibody to IL-6
Specificity:	IL-6 pAb detects endogenous levels of IL-6 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Recombinant full length Human IL-6.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 23 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1mg/ml in PBS?with?0.1%?Sodium?Azide,?50%?Glycerol.

Target

Function:	Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation.
Involvement in Disease:	Rheumatoid arthritis systemic juvenile: An inflammatory articular disorder with systemic-onset beginning before the age of 16. It represents a subgroup of juvenile arthritis associated with severe extraarticular features and occasionally fatal complications. During active phases of the disorder, patients display a typical daily spiking fever, an evanescent macular rash, lymphadenopathy, hepatosplenomegaly, serositis, myalgia and arthritis.
Sequence Similarities:	Belongs to the IL-6 superfamily.
Post-Translational Modification:	N- and O-glycosylated.
Cellular locations:	Secreted.
Database Links:	Entrez Gene: 3569?Human Entrez Gene: 16193?Mouse Entrez Gene: 24498?Rat Omim: 147620?Human SwissProt: P05231?Human SwissProt: P08505?Mouse SwissProt: P20607?Rat Unigene: 654458?Human Unigene: 1019?Mouse Unigene: 9873?Rat
Synonyms:	Interleukin BSF 2 Antibody B cell differentiation factor Antibody B cell stimulatory factor 2 Antibody B-cell stimulatory factor 2 Antibody BSF 2 Antibody BSF-2 Antibody BSF2 Antibody CDF Antibody CTL differentiation factor Antibody Cytotoxic T cell differentiation factor Antibody Hepatocyte stimulating fact Antibody Hepatocyte stimulating factor Antibody Hepatocyte stimulatory factor Antibody HGF Antibody HPGF Antibody HSF Antibody Hybridoma growth factor Antibody Hybridoma growth factor Interferon beta-2 Antibody Hybridoma plasmacytoma growth factor Antibody IFN-beta-2 Antibody IFNB2 Antibody IL 6 Antibody IL-6 Antibody IL6 Antibody IL6 protein Antibody IL6_HUMAN Antibody Interferon beta 2 Antibody Interferon beta-2 Antibody Interleukin 6 Antibody Interleukin 6 (interferon beta 2) Antibody Interleukin BSF 2 Antibody Interleukin BSF2 Antibody Interleukin-6 Antibody Interleukin6 Antibody
Information:	Target information shown above is from the UniProt Consortium.