Anti-DCTN1 Antibody |产品详情|进口榴莲视频免费观看采购网

您好，欢迎来到榴莲视频下载地址入口生物网站！请登录注册

我的订单 | 联系榴莲视频下载地址入口 | 在线客服QQ：3012681483 | 客服电话：400-968-7988 | 工作时间：08:30-17:30

主营产品： ELISA8008APP幸福宝榴莲、抗体、补体血清、兔补体、干扰素、小鼠测温仪、进口榴莲视频免费观看、Quidel代理、Swant代理、PBL Assay Science代理

网站首页产品中心代理品牌新闻资讯资源中心关于榴莲视频下载地址入口

所在位置：首页 > 产品中心 > Antibodies > Antibodies产品

订购信息

上海榴莲视频下载地址入口生物科技公司

Tel:400-968-7988 021-33779008

Anti-DCTN1 Antibody

品牌：Antibodies

货号：

规格：100µg

货期：

应用：

咨询客服

立即购买加入购物车

Anti-DCTN1 Antibody

商品详情参考文献相关资料

Overview

Name:	Anti-DCTN1 Antibody See all DCTN1 primary antibodies
Description:	Goat polyclonal antibody to DCTN1.
Applications:	ELISA, WB, IHC, ICC
Reactivity:	Human, Mouse
Immunogen:	Synthetic peptide corresponding to Human DCTN1 (C terminal).
Sequence:	C-QEQLHQLHSRLIS
Host:	Goat
Clonality:	Polyclonal
Isotype:	IgG
Conjugate:	Unconjugated
Purification:	Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration:	100 μg at 0.5 mg/ml.
Product Form:	Liquid
Formulation:	Supplied in Tris Buffered Saline, pH 7.30, with 0.02% Sodium Azide and 0.5% BSA.
Storage:	Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.

Target

Function:	Plays a key role in dynein-mediated retrograde transport of vesicles and organelles along microtubules by recruiting and tethering dynein to microtubules. Binds to both dynein and microtubules providing a link between specific cargos, microtubules and dynein. Essential for targeting dynein to microtubule plus ends, recruiting dynein to membranous cargos and enhancing dynein processivity (the ability to move along a microtubule for a long distance without falling off the track). Can also act as a brake to slow the dynein motor during motility along the microtubule. Can regulate microtubule stability by promoting microtubule formation, nucleation and polymerization and by inhibiting microtubule catastrophe in neurons. Inhibits microtubule catastrophe by binding both to microtubules and to tubulin, leading to enhanced microtubule stability along the axon. Plays a role in metaphase spindle orientation. Plays a role in centriole cohesion and subdistal appendage organization and function. Its recruitement to the centriole in a KIF3A-dependent manner is essential for the maintenance of centriole cohesion and the formation of subdistal appendage. Also required for microtubule anchoring at the mother centriole. Plays a role in primary cilia formation.
Sequence Similarities:	Belongs to the dynactin 150 kDa subunit family.
Post-Translational Modification:	Ubiquitinated by a SCF complex containing FBXL5, leading to its degradation by the proteasome.
Cellular locations:	Cytoplasm. Cytoplasm > Cytoskeleton. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome. Cytoplasm > Cytoskeleton > Microtubule organizing center > Centrosome > Centriole. Cytoplasm > Cytoskeleton > Spindle. Nucleus envelope. Cytoplasm > Cell cortex. Localizes to microtubule plus ends. Localizes preferentially to the ends of tyrosinated microtubules (PubMed:16954346). Localization at centrosome is regulated by SLK-dependent phosphorylation. Localizes to centrosome in a PARKDA-dependent manner. PLK1-mediated phosphorylation at Ser-179 is essential for its localization in the nuclear envelope (By similarity). Localizes to the subdistal appendage region of the centriole in a KIF3A-dependent manner (PubMed:23386061).
Database Links:	Entrez Gene: 1639?Human Entrez Gene: 13191?Mouse Omim: 601143?Human SwissProt: Q14203?Human SwissProt: O08788?Mouse Unigene: 516111?Human Unigene: 6919?Mouse
Synonyms:	150 kDa dynein associated polypeptide Antibody 150 kDa dynein-associated polypeptide Antibody DAP 150 Antibody DAP-150 Antibody DAP150 Antibody DCTN 1 Antibody DCTN1 Antibody DCTN1_HUMAN Antibody DP 150 Antibody DP-150 Antibody DP150 Antibody Dynactin 1 Antibody Dynactin 1 (p150 Glued (Drosophila) homolog) Antibody Dynactin 1 (p150 glued homolog Drosophila) Antibody Dynactin subunit 1 Antibody Dynactin1 Antibody HMN7B Antibody p135 Antibody p150 glued Antibody p150 Glued (Drosophila) homolog Antibody p150 glued homolog Antibody p150(GLUED) DROSOPHILA HOMOLOG OF Antibody p150-glued Antibody p150glued Antibody
Information:	Target information shown above is from the UniProt Consortium.