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 Anti-p63 Protein Antibody |产品详情|进口榴莲视频免费观看采购网





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    Anti-p63 Protein Antibody
    品牌:Antibodies
    货号:
    规格:5ml
    货期:

    Anti-p63 Protein Antibody

    商品详情 参考文献 相关资料
    Name: Anti-p63 Protein Antibody
    See all p63 primary antibodies
    Description: Mouse monoclonal (4A4) antibody to p63 Protein.
    Specificity: p63 protein (nuclear), 6 Isotypes.
    Applications: IHC
    Reactivity: Human, Mouse, Rat?
    Immunogen: Recombinant human p63 protein (aa 1-205).
    Host: Mouse
    Clonality: Monoclonal
    Clone: 4A4
    Isotype: IgG2a
    Conjugate: Unconjugated
    Product Form: Liquid
    Formulation: Supplied in Phosphate Buffered Saline with 0.09% Sodium Azide.
    Storage: Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
    General Notes: p63 is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei) . It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80% of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma.
    Function: Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. Involved in Notch signaling by probably inducing JAG1 and JAG2. Activates RIPK4 transcription (By similarity). Plays a role in the regulation of epithelial morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may govern the maintenance of epithelial stem cell compartments and regulate the initiation of epithelial stratification from the undifferentiated embryonal ectoderm. Required for limb formation from the apical ectodermal ridge. Activates transcription of the p21 promoter (By similarity).
    Tissue Specificity: Widely expressed, notably in thymus, prostate, placenta, and skeletal muscle, although the precise isoform varies according to tissue type. Progenitor cell layers of skin, breast and prostate express high levels of DeltaN-type isoforms.
    Sequence Similarities: Belongs to the p53 family.
    Post-Translational Modification: May be sumoylated.
    Cellular locations: Nucleus.
    Database Links:
  1. Entrez Gene: 8626?Human
  2. Entrez Gene: 22061?Mouse
  3. Entrez Gene: 246334?Rat
  4. Omim: 603273?Human
  5. SwissProt: Q9H3D4?Human
  6. SwissProt: O88898?Mouse
  7. SwissProt: Q9JJP6?Rat
  8. Unigene: 137569?Human
  9. Unigene: 20894?Mouse
  10. Unigene: 42907?Rat
  11. Synonyms:
  12. AIS Antibody
  13. Amplified in squamous cell carcinoma Antibody
  14. B(p51A) Antibody
  15. B(p51B) Antibody
  16. Chronic ulcerative stomatitis protein Antibody
  17. CUSP Antibody
  18. DN p63 alpha 1 Antibody
  19. DNp63 Antibody
  20. EEC3 Antibody
  21. id:ibd3516 Antibody
  22. Keratinocyte transcription factor Antibody
  23. Keratinocyte transcription factor KET Antibody
  24. KET Antibody
  25. LMS Antibody
  26. MGC115972 Antibody
  27. MGC192897 Antibody
  28. NBP Antibody
  29. OFC8 Antibody
  30. OTTHUMP00000209732 Antibody
  31. OTTHUMP00000209733 Antibody
  32. OTTHUMP00000209734 Antibody
  33. OTTHUMP00000209735 Antibody
  34. OTTHUMP00000209737 Antibody
  35. OTTHUMP00000209738 Antibody
  36. OTTHUMP00000209739 Antibody
  37. OTTHUMP00000209740 Antibody
  38. OTTHUMP00000209741 Antibody
  39. OTTHUMP00000209742 Antibody
  40. OTTHUMP00000209743 Antibody
  41. OTTHUMP00000209744 Antibody
  42. p40 Antibody
  43. p51 Antibody
  44. P51/P63 Antibody
  45. p53-related protein p63 Antibody
  46. p53CP Antibody
  47. p63 Antibody
  48. P63_HUMAN Antibody
  49. p73H Antibody
  50. p73L Antibody
  51. RHS Antibody
  52. SHFM4 Antibody
  53. TAp63alpha Antibody
  54. TP53CP Antibody
  55. TP53L Antibody
  56. TP63 Antibody
  57. TP73L Antibody
  58. Transformation related protein 63 Antibody
  59. Transformation-related protein 63 Antibody
  60. Trp53rp1 Antibody
  61. Trp63 Antibody
  62. Tumor protein 63 Antibody
  63. Tumor protein p53-competing protein Antibody
  64. Tumor protein p53-like Antibody
  65. Tumor protein p63 Antibody
  66. Tumor protein p63 deltaN isoform delta Antibody
  67. Tumor protein p73 Antibody
  68. Tumor protein p73-like Antibody
  69. Information: Target information shown above is from the UniProt Consortium.
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