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Anti-Lamin B1 (L75) Antibody

品牌：Antibodies

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规格：50µl

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Anti-Lamin B1 (L75) Antibody

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Overview

Name:	Anti-Lamin B1 (L75) Antibody See all Lamin B1 primary antibodies
Description:	Rabbit polyclonal antibody to Lamin B1 (L75)
Specificity:	Lamin B1 (L75) pAb detects endogenous levels of Lamin B1 protein.
Applications:	WB, IHC
Reactivity:	Human, Mouse, Rat
Immunogen:	Synthetic peptide, corresponding to amino acids 50-100 of Human Lamin B1.
Host:	Rabbit
Clonality:	Polyclonal
Conjugate:	Unconjugated
Molecular Weight:	~ 68 kDa
Purity:	The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE).
Product Form:	1 mg/ml in Phosphate buffered saline (PBS) with 0.05% sodium azide, approx. pH 7.2.

Target

Function:	Lamins are components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane, which is thought to provide a framework for the nuclear envelope and may also interact with chromatin.
Involvement in Disease:	Leukodystrophy, demyelinating, autosomal dominant, *****-onset: A slowly progressive and fatal demyelinating leukodystrophy, presenting in the fourth or fifth decade of life. Clinically characterized by early autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS. It differs from multiple sclerosis and other demyelinating disorders in that neuropathology shows preservation of oligodendroglia in the presence of subtotal demyelination and lack of astrogliosesis.
Sequence Similarities:	Belongs to the intermediate filament family.
Post-Translational Modification:	B-type lamins undergo a series of modifications, such as farnesylation and phosphorylation. Increased phosphorylation of the lamins occurs before envelope disintegration and probably plays a role in regulating lamin associations.
Cellular locations:	Nucleus inner membrane.
Database Links:	Entrez Gene: 4001?Human Entrez Gene: 16906?Mouse Entrez Gene: 116685?Rat Omim: 150340?Human SwissProt: P20700?Human SwissProt: P14733?Mouse SwissProt: P70615?Rat Unigene: 89497?Human Unigene: 4105?Mouse Unigene: 11362?Rat
Synonyms:	ADLD Antibody Lamin B1 Antibody Lamin-B1 Antibody LMN Antibody LMN2 Antibody LMNB Antibody Lmnb1 Antibody LMNB1_HUMAN Antibody MGC111419 Antibody OTTHUMP00000159218 Antibody
Information:	Target information shown above is from the UniProt Consortium.